UNLABELLED BACKGROUND Bleeding remains a potentially lethal complication of cardio-pulmonary bypass (CPB) surgery. The purpose of this study was to obtain a better insight into in vitro thrombin generation in the context of CPB. METHODS We used Calibrated Automated Thrombography to assess blood coagulation of 10 low-risk patients operated for valve replacement with CPB, under 2 experimenta...

Congenital aortic stenosis is a relatively common disease. It is the one malformation predisposing to sudden death in children. Surgical attempts at correction of critical congenital aortic stenosis have been reported within recent years, but there are no large series with adequate longterm follow up of the post-operative course of children with aortic stenosis. The present report is based on o...

The development of a mild metabolic acidosis during general anaesthesia has been reported by many workers (Bunker, Brewster, Smith, and Beecher, 1952; Pontius, Watkins, Manheim, Allen, Sauvage, and Gross, 1958; Robertson and Frazer, 1958). Likewise the early onset of a slight but definite metabolic acidosis has been observed in dogs during cyclopropane anaesthesia and the degree of acidosis was...

Many intracardiac procedures can currently be performed on the heart only after it has been arrested, and the patient has been placed on cardio-pulmonary bypass. We have developed a new method for operating on multiple targets inside the beating heart, and describe a procedure for accessing them under virtual-reality (VR)-assisted image guidance that combines real-time ultrasound with a virtual...

One of the incapacitating postoperative morbidities that was seen in all types of surgery is Postoperative cognitive dysfunction (POCD). The elder patients and also cardiac surgery patients (CSPs) are at particular risk. Additionally it was shown that the severity, extension of impairment and the incidence rate of POCD is more in CSPs. POCD is a dementia-like symptoms disorder is characterized ...

The use of nonpulsatile flow during extracorporeal circulation remains popular despite theoretical advantages of pulsatile cardiopulmonary bypass (CPB). Pulsatile CPB is considered to be more physiological than nonpulsatile flow as the pulsatile energy ensures the patency of the vascular bed and mechanical motion of tissue fluid around the cell membrane, improves microcirculation and enhances d...

Method The study group was consisted of 1186 consecutive patients who underwent cardiac surgery from June 2012 to April 2015 in a single Cardiothoracic Surgery Department. The following 21 peri-operative variables have been investigated: Age, Gender, Euroscore II, Body Mass Index (BMI),Smoking habit, Diabetes Mellitus, Insulin use, pre-op Glomerular Filtration Rate (GFR), Peripheral Vascular Di...

An experimental study is performed to examine the breaking of an air bubble in the Row passage of a simulated cardiopulmonary bypass system by means of a flow constriction. The purpose of the study is to discover a geometry of the flow constriction which is efficient in breaking air bubbles while providing the least resistance to the flow of blood. i.e. to develop a new device for the oxygenati...

BACKGROUND To date, only limited data exist about the use of xenon as an anaesthetic agent in patients undergoing cardiac surgery. The favourable cardio- and neuroprotective properties of xenon might attenuate postoperative complications, improve outcome, and reduce the incidence of delirium. Thus, the aims of this study were to investigate the feasibility and safety of balanced xenon anaesthes...