Background: Neuroinflammation, as a major outcome of microglia activation, is an important factor for progression of neurodegenerative disorders including Alzheimer's disease and Parkinson's disease. Microglial cells, as the first-line defense in the central nervous system, act as a source of neurotoxic factors such as nitric oxide (NO), a free radical which is involved in neuronal cell death. ...

objective: ionizing radiation produces free radicals which induce dna damage and cell death. origanum vulgare leaf extract (ovle) is a natural compound and its capability of scavenging free radicals and its antioxidant activity have been demonstrated by many researchers. in this study, using micronucleus assay, radioprotective effect of ovle against clastogenic and cytotoxic effect of gamma irr...

BACKGROUND Despite great advances in the treatment of burn patients, useful prognostic markers are sparse. During the past years there has been increasing interest in circulating plasma cell free DNA as a potential marker for tissue injury. We have developed a rapid direct fluorescent assay for cell free DNA quantification that allows obtaining accurate, fast, and inexpensive measurements. OB...

Lactic acid bacteria are one of the potential natural remedies used worldwide, commonly known as probiotics. Here, aim this research investigation was to isolate a probiotic Lactobacilli strain, YLM015, from popular Korean fermented vegetable “Kimchi” and evaluate its anti-viral against influenza virus A (IFVA) H1N1 using MDCK cell line in vitro, embryonated eggs ovo. The YML015 strain selected...

Many investigators have used xenogeneic, especially murine stromal cells and fetal calf serum to maintain and expand human stem cells. The proliferation and expansion of human hematopoietic stem cells in ex vivo culture were examined with the goal of generating a suitable protocol for expanding hematopoietic stem cells for patient transplantation. Using primary fetal liver cells, we established...

Background:  Cell viability is an important factor in radiation therapy and thus is a method to quantify the effect of the therapy. Materials and Methods: The viability of human hepatoma (HepG2) cells exposed to radiation was evaluated by both the MTT and Trypan blue assays. The cells were seeded on 96 well-plates at a density of 1 x 104 cells/well, incubated overnight, and irradiated with...

compounds containing triazene ring structure are cytotoxic agents and clinically used as antitumor alkylating agents. in this study, a series of triazene derivatives holding alkyl and aryl moieties were synthesized and proved to be potent cytotoxic agents in-vitro particularly against eight cancer cell lines (pc3, ht29, hela, hl60, jurkat, k562, mcf7, hepg2) and a non-cancerous cell line (huvec...

the ethyl acetate partition of dried methanolic extract of aerial parts of euphorbia microsciadia (euphorbiaceae) afforded three pentacyclic triterpenes, betulinic acid (1) from lupane type, oleanolic acid (2) from oleane type and ursolic acid (3) from ursane type triterpenes that are reported for the first time in this plant. these three compounds were structurally compared through their mass ...