INTRODUCTION Hypotonia, or decreased muscle tone, is a common diagnosis in infants and children. The presence of hypotonia is generally indicative of an underlying neuromuscular or genetic disorder, including Down syndrome. In conjunction with decreased muscle tone, children with hypotonia typically exhibit ligamentous laxity and instability of the lower limb joints, which may result in abnorma...

Zellweger syndrome, a paradigm of human peroxisomal disorders is characterized by dysmorphic features, hypotonia, severe neuro-developmental delay, hepatomegaly, renal cysts, sensorineural deafness and retinal dysfunction. This is a case report of a baby boy born with facial dysmorphism, profound hypotonia, seizures, and hepatomegaly. The diagnosis was not evident initially but only later when ...

OBJECTIVE: To describe 6 patients with less than 3 years of age that were diagnosed with Prader-Willi syndrome (PWS) due to hypotonia, poor sucking, slight facial anomalies and minor abnormalities of hands and feet. PWS is a neurobehavioural disorder characterized by two distinct phases; in the first, the neonate presents variable degree of hypotonia, feeding problems with none or poor sucking;...

Extreme mobility of the joints is of great advantage to an acrobat, permitting him to assume fascinating postures. When the condition appears in infancy, however, it may be quite alarming, as it may easily be confused with serious organic disease if the features are not known. There are two basic disturbances in this condition: (1) Abnormal mobility of the bones at the joints, and (2) extreme h...

The characteristics of idiopathic hypotonic gait are poorly understood. The purpose of this study was to identify biomechanical parameters that differentiate between children with hypotonia and an age-matched control group. Twelve children with idiopathic hypotonia, aged 6–13 years, participated in the study. Twenty-two children with no known disorders, aged 6–13 years, served as a control grou...

Extreme mobility of the joints is of great advantage to an acrobat, permitting him to assume fascinating postures. When the condition appears in infancy, however, it may be quite alarming, as it may easily be confused with serious organic disease if the features are not known. There are two basic disturbances in this condition: (1) Abnormal mobility of the bones at the joints, and (2) extreme h...

A 5 year old female child from a well-monitored, full term pregnancy with no specific history of ataxia, hypotonia and global developmental delay.