The immunogenicity of the human papillomavirus (HPV)-16/18 AS04-adjuvanted vaccine (Cervarix®, GlaxoSmithKline Biologicals) administered according to its licensed vaccination schedule (3-dose, 3D) and formulation (20 μg of each HPV antigen; 20/20F) has previously been demonstrated. This partially-blind, controlled, randomized trial (NCT00541970) evaluated 2-dose (2D) schedules using the license...

This study explored the knowledge, attitude, practice and barriers to prescribe human papillomavirus (HPV) vaccines among private primary care physicians in Hong Kong. A self-administered questionnaire survey was conducted by sending letters to doctors who had joined a vaccination program for school girls. From 720 surveys sent, 444 (61.7%) completed questionnaires were returned and analyzed. F...

which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Cervical cancer is considered a preventable disease because it has causative agent called Human Papilloma Virus (HPV). HPV infection was detected in up to 99% of women with squamous cell carcinoma of uterine cervix. Two HPV vaccines are approv­ ed by the U.S...

as a qHPV vaccine and Cervarix (Glaxo-SmithKline, Middlesex, UK) as a bivalent HPV (biHPV) vaccine. Both of these vaccines are effective for HPV subtypes 16 and 18, and Gardasil is effective against the two additional subtypes 6 and 11. The biHPV vaccine was approved for development in 1998, received FDA approval in 2009, and is now licensed in more than 100 countries and approved in more than ...

F ull-page advertisements inviting parents to immunize their preadolescent boys against human papillomavirus (HPV) have rekindled the debate over who should receive the world’s first cancer vaccine. In the ads for Merck’s Gardasil vaccine ( Parade magazine, April 25, 2010), two cherubic faces — one of a mischievous-looking boy in need of a haircut, the other of a tomboyish girl with braces on h...

Human papilloma virus (HPV)-16 and -18 are responsible for approximately 70% of invasive cervical cancers worldwide. Other oncogenic HPV types account for almost all the remainder. Importantly, HPV-45 and -31 account for approximately 10%. HPV-18 and -45, along with HPV-16, are found in over 90% of endocervical adenocarcinomas. HPV-45 is the third most frequent HPV type in cervical carcinoma an...

HPV vaccines are highly effective at preventing anogenital HPV infections and the neoplastic diseases that they cause (Herrero et al., 2015). Like other licensed anti-viral prophylactic vaccines, the HPV vaccines are thought to function primarily by inducing antibodies that bind the virus, thereby preventing infection (Schiller and Lowy, 2012). In the case of the three licensed HPV vaccines, th...

Globally, cervical cancer is one of the most deadly forms of cancer affectingwomen—killingmore than 270,000 people every year. Themajority of these deaths (85%, according to theWHO) occur in developing countries. A global health priority, therefore, is to provide low-cost, highly effective cervical cancer prevention, detection, and control options to all women who need them. The human papilloma...