The chemokine CXCL12 is highly expressed in gynecologic tumors and is widely known to play a biologically relevant role in tumor growth and spread. Recent evidence suggests that CXCL16, a novel chemokine, is overexpressed in inflammation-associated tumors and mediates pro-tumorigenic effects of inflammation in prostate cancer. We therefore analyzed the expression of CXCL12 and CXCL16 and their ...

background and objective: to estimate the risk of human papilloma virus (hpv) infection for cervical malignancies, we conducted a case-control study in southern iran (hormozgan province). materials and methods: for this purpose,52 paraffin embedded blocks with exact diagnosis of cervical carcinoma(50 carcinomas and 2 carcinomas in situ) from 2001 to 2006 and 52 praffin embedded blocks of cervic...

The infection of uterine cervical epithelial cells by oncogenic, high-risk human papilloma viruses (HR-HPVs) may lead to the development of cervical carcinoma. Of note, the incidence of this tumor is significantly increased in women infected by both HR-HPV and human immunodeficiency virus (HIV)-1. In this regard, previous studies have linked the HIV-1 Tat protein, a trans-activator of viral gen...

Cervical cancer, the second most common cancer in women, develops through well-defined precursor lesions with potential to progress to invasive disease if not properly detected and eradicated. In cervical carcinogenesis, human papillomavirus (HPV) plays an important causal role. Besides the evidental causal role in cervical carcinogenesis, HPV is an important prognostic factor for disease progr...

Ophiocoma erinaceus Muller &Troschel (Ophiocomidae) is part of the extensive group of echinoderm that contains bioactive metabolites. As, the anti cancer potential of brittle star saponin has not been reported against cervical cancer, the present study was conducted to evaluate the anticancer effect of extracted crude saponin. Saponin extraction was conducted using conventional method such as f...

UNLABELLED The aim of this study was to find a possible clinical use of the tail-interacting protein of 47 kDa (TIP47) and further document its expression in smear cytology, different cervical dysplasias, invasive cervical cancer and metastasis. PATIENTS AND METHODS A new polyclonal anti-TIP47 antibody was developed and used on smears and histological cervix sections of sixty women with diffe...

Abstract Cervical cancer is a typical characterized by abnormal cell growth in the cervical area. Ginkgo biloba L. deciduous tree of genus , possessing anti-cancer effects. The aim this study was to explore effect strain J1 from on apoptosis cells. Bacteriostatic activity test, MTT assay and Flow cytometry were used study. Crude extract fermentation reduced cancer. crude broth had good inhibito...

amoebiasis of the uterine cervix is an extremely rare entity and presentation as carcinoma cervix has only been reported once in the extensively searched english literature. it can clinically simulate cervical malignancy by virtue of surface papillomatous and overall ulcerated and necrotic appearance. we present a case of amoebic cervicitis in a 55-year old female which was suspected to be a sq...

Objective: To investigate the clinical value of T lymphocyte subsets and NK cells in peripheral blood of patients with high-risk HPV infection and different cervical lesions. Methods: CD3+, CD4+, CD8+ lymphocyte subsets and CD16+CD56+ cells in specimens of peripheral blood of 212 healthy control and 2167 patients with high-risk HPV infection and different cervical lesions were detected by flow ...

Patients with cervical carcinoma (CC) are frequently immunocompromised. Dendritic cells (DCs) are potent antigen-presenting cells. Using multicolor flow cytometry, the percentages of CD11c+ (DC1) and CD123+ (DC2) subsets, were determined in the peripheral blood of 37 patients with cervical carcinoma (CC), 54 patients with CIN, and 62 healthy individuals. A substantial reduction of circulating d...