OBJECTIVE The aim of this study is to determine if simvastatin pretreatment would change clomiphene response in clomiphene citrate-resistant (CC-R)women with (PCOS). MATERIALS AND METHODS This quasi experimental study included twenty five clomiphene resistant women with PCOS. All patients received cyclic oral contraceptives pills (OCP) (30µg of ethinyl estradiol and 150µg of desogestrol) from...

BACKGROUND AND AIMS Aluminium (Al) stimulates the efflux of citrate from apices of rice bean (Vigna umbellata) roots. This response is delayed at least 3 h when roots are exposed to 50 microm Al, indicating that some inducible processes leading to citrate efflux are involved. The physiological bases responsible for the delayed response were examined here. METHODS The effects of several antago...

Background: One of the most common causes of infertility in women is ovulatory dysfunction (PCOS) and the choice of treatment is clomiphene citrate. One of the mechanism of dichotomy between the rate of ovulation and pregnancy is anti estrogenic effects of clomiphene citrate on endometrium. According to its long half life, the anti estrogenic effects probably exacerbate in consecutive cycles. W...

Aluminium (Al) stress was imposed on 285 lentil genotypes at seedling stage under hydroponics to study its effects on morpho-physiological traits where resistant cultigens and wilds showed minimum reduction in root and shoot length and maximum root re-growth (RRG) after staining. Molecular assortment based on 46 simple sequence repeat (SSR) markers clustered the genotypes into 11 groups, where ...

Background/Objective: To evaluate factors which increase the chance of ovulation and pregnancy after laparoscopic ovarian electerocauterization (LEC) in Clomiphene Citrate (CC) resistant polycystic ovarian syndrome (PCOS) patients.Methods: An experimental prospective study was carried out in the infertility division of a university teaching hospital. Two hundred and ninety-nine women with PCOS ...

In order to evaluate the effects of short course administration of dexamethasone (DEX) combined with clomiphene citrate (CC) in CC-resistant patients with polycystic ovary syndrome (PCaS) and normal DHEAS, a prospective, double blind, placebo controlled, randomized study was undertaken at referral university hospitals, Two-hundred and thirty women with PCOS and normal DHEAS who failed to ...

We read with interest the comprehensive review of Krajčová et al. [1] on propofol infusion syndrome (PRIS). Of particular importance is the high (51 %!) associated mortality which is mainly determined by cardiac failure, therapy-resistant bradyarrhythmia, metabolic acidosis, and rhabdomyolysis [1]. The authors provide a detailed insight on the pathophysiologic mechanism(s) underlying PRIS but d...

Previous work (Birnberg, Jayroe, Hanson 1982 Plant Physiol 70: 511-516) demonstrated that corn mitochondria (Zea mays L.) can accumulate citrate by a malate- and phosphate-independent proton symporter. This uptake and symport of other ions were investigated. Passive swelling experiments indicated that corn mitochondria can accumulate several other anions by proton symport, but only isocitrate i...