نتایج جستجو برای: coagulation activity

تعداد نتایج: 1175523  

Journal: :Journal of experimental & clinical cancer research : CR 2016
Liangliang Zhao Yayan Bi Junjie Kou Jialan Shi Daxun Piao

BACKGROUND Colon cancer is invariably accompanied by altered coagulation activity; however, the precise role of phosphatidylserine (PS) in the hypercoagulable state of colon cancer patients remains unclear. We explored the exposure of PS on platelets and microparticles (MPs), and evaluate its role in procoagulant activity in colon cancer patients. METHODS PS-positive platelets and MPs, mainly...

Journal: :The Journal of Experimental Medicine 1982
BS Schwartz GA Levy DS Fair TS Edgington

Murine lymphoid cells respond rapidly to bacterial lipopolysaccharide or antigen-antibody complexes to initiate or accelerate the blood coagulation pathways. The monocyte or macrophage has been identified as the cellular source, although lymphocyte collaboration is required for the rapid induction of the procoagulant response. This procoagulant activity is identified in the present study as a d...

Journal: :The Journal of clinical investigation 2012
A Phillip Owens Freda H Passam Silvio Antoniak Stephanie M Marshall Allison L McDaniel Lawrence Rudel Julie C Williams Brian K Hubbard Julie-Ann Dutton Jianguo Wang Peter S Tobias Linda K Curtiss Alan Daugherty Daniel Kirchhofer James P Luyendyk Patrick M Moriarty Shanmugam Nagarajan Barbara C Furie Bruce Furie Douglas G Johns Ryan E Temel Nigel Mackman

Hypercholesterolemia is a major risk factor for atherosclerosis. It also is associated with platelet hyperactivity, which increases morbidity and mortality from cardiovascular disease. However, the mechanisms by which hypercholesterolemia produces a procoagulant state remain undefined. Atherosclerosis is associated with accumulation of oxidized lipoproteins within atherosclerotic lesions. Small...

2009
Alexander Breitenstein Felix C. Tanner Thomas F. Lüscher

Under physiological conditions, the coagulation system is designed to maintain the circulating blood in a fluid state, but act towards restoration of vascular integrity by rapid clot formation after vessel injury. Historically, the coagulation cascade was divided into 2 major systems: the extrinsic and the intrinsic pathway (Figure 1).1 The tissue factor (TF)factor VII/VIIa (FVII/FVIIa) complex...

Journal: :The Journal of Experimental Medicine 1984
M P Bevilacqua J S Pober G R Majeau R S Cotran M A Gimbrone

Human monocyte-derived interleukin 1 (IL-1) was found to be a potent inducer of procoagulant activity in cultured human vascular endothelium. IL-1-induced human umbilical vein endothelial cell procoagulant activity (HEC-PCA) was transiently expressed, manifest in intact cell monolayers, and required protein synthesis. Data obtained with coagulation factor-deficient plasma and a goat anti-human ...

2007

Total endothelial destruction results in the exposure of sub-endothelial collagen fibers causing platelet aggregation, adherence, and release of platelet-related factors. This series of events initiates the intrinsic pathway of blood coagulation by activating factor XII. Ideally, sclerosing solutions otherwise should not cause activation or release of thromboplastic activity because this would ...

پایان نامه :دانشگاه آزاد اسلامی واحد کرمانشاه - پژوهشکده زبان و گویش 1393

abstract the purpose of this study is twofold: on the one hand, it is intended to see what kind of noticing-the –gap activity (teacher generated vs. learner generated) is more efficient in teaching l2 grammar in classroom language learning. on the other hand, it is an attempt to determine which approach of the noticing-the-gap- activity is more effective in the long- term retention of grammar...

2017
Jiong-Wei Wang Ya-Nan Zhang Siu Kwan Sze Sander M van de Weg Flora Vernooij Arjan H Schoneveld Sock-Hwee Tan Henri H Versteeg Leo Timmers Carolyn S P Lam Dominique P V de Kleijn

Plasma extracellular vesicles (EVs) are lipid membrane vesicles involved in several biological processes including coagulation. Both coagulation and lipid metabolism are strongly associated with cardiovascular events. Lowering very-low- and low-density lipoprotein ((V)LDL) particles via dextran sulphate LDL apheresis also removes coagulation proteins. It remains unknown, however, how coagulatio...

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