Genome-wide association studies and meta-analyses implicated that increased risk of developing Alzheimer's diseases (AD) has been associated with the ABCA7, APOE, BIN1, CASS4, CD2AP, CD33, CELF1, CLU, CR1, DSG2, EPHA1, FERMT2, HLA-DRB1, HLA-DRB4, INPP5D, MEF2C, MS4A4A, MS4A4E, MS4A6E, NME8, PICALM, PLD3, PTK2B, RIN3, SLC24A4, SORL1, and ZCWPW1 genes. In this study, we assessed whether single nu...

aging has negative effects on motor and cognitive functions, so it is essential to identify appropriate strategies to prevent the decrease of motor and cognitive functions. the aim of this research was to investigate the effect of vitamin e supplement on motor activity and spatial learning in aged rats. 36 male albino – wistar aged rats were assigned to three groups of control, vitamin e and sh...

Cognitive aging is a leading public health concern with the increasing aging population, but there is still lack of specific interventions directed against it. Recent studies have shown that cognitive function is intimately affected by systemic milieu in aging brain, and improvement of systemic environment in aging brain may be a promising approach for rejuvenating cognitive aging. Here, we sou...

Cognitive functioning is critical as in our daily life a host of real-world complex decisions in high-stakes markets have to be made. The decision-making process can be vulnerable to environmental stressors. Summarizing the growing economic and epidemiologic evidence linking air pollution, cognition performance and real-world decision-making, we first illustrate key physiological and psychologi...

In recent years, as the aging population grows, aging-induced cognitive impairments including dementia and Alzheimer's disease (AD) have become the biggest challenges for global public health and social care. Therefore, the development of potential therapeutic drugs for aging-associated cognitive impairment is essential. Metabolic dysregulation has been considered to be a key factor that affect...

Human cognitive aging has been too long neglected and underappreciated for its critical importance to quality of life in old age. The articles in this session present novel approaches to improving cognitive function in normal aging persons with drugs and interventions that are based on findings in epidemiology, studies in aged animals, and in vitro research. In addition, since aging is the prim...

T hIS special issue presents methodologically innovative work that advances our understanding of the relationship between cognitive performance and affect, in particular highlighting the contribution of brain to behavior. Studies investigating the effects of aging on brain anatomy and physiology suggest targeted areas which are most affected by aging, and are characterized by cerebral atrophy, ...

Characterizing the cognitive declines associated with aging, and differentiating them from the effects of disease in older adults, are important goals for human neuroscience researchers. This is also an issue of public health urgency in countries with rapidly aging populations. Progress toward understanding cognitive aging is complicated by numerous factors. Researchers interested in cognitive ...

Until the mid 1990s, available evidence regarding neurocognitive aging could be summarized in a simple statement: cognitive deficits in healthy older adults are largest for tasks that are highly dependent on executive control processes because these processes are mediated by the prefrontal cortex (PFC), which is the region most disrupted by healthy aging. This view, known as the frontal lobe hy...