we investigated the vasodilatory effect of isoprenaline at large vessels (aorta, renal ans saphenous arteries, vena cava, renal and saphenous veins) in doxorbicin-induced model of heart failure. thirty saline-treated (normal group) and thirty doxorubicin treated rabbits (1 mg/kg administered intravenously twice weekly for 8 weeks) were studied after 16 weeks of treatment. chronic heart failure ...

The traditional methods for the assessment of insulin sensitivity yield only a single index, not the whole dose-response curve information. This curve is typically characterized by a maximally insulin-stimulated glucose clearance (Cl(max)) and an insulin concentration at half-maximal response (EC(50)). We developed an approach for estimating the whole dose-response curve with a single in vivo t...

Procedure This study included 44 patients (479 courses) who received a median dose of 5.92 g/m of MTX (interquartile range (IQR) 2.37 g/m) in a 4-hr infusion. The mean area under the concentration–time curve (AUC) estimated by parametric methods (non-parametric expectation maximization, NPEM), and the mean concentration at the end of the infusion were considered to be the exposure parameters. T...

The relationship between the binding of L-triiodothyronine (T3) to nuclear receptors and the induction of growth hormone synthesis was examined in cultured GH1 cells, a rat pituitary cell line. After 24 hr, T3 induced a maximal 4-fold increase in the rate of growth hormone wynthesis; the T3 concentration that induced a half-maximal increase was 0.22 nM. The biologic dose-response curve was shif...

The pharmacological reactivity of guinea pig ileum to ethanol leaf extract of Amaranthus caudatus and Solanum melongena were determined in vitro. Parameters evaluated include the threshold value and the concentration ratio (CR). The potency of the plant extracts as expressed by EC50, the Emax (maximum response) and its corresponding concentration were determined from the concentration response ...

carum carvi (cc) is a grassy plant which is believed to have several therapeutic effects, including anti-asthmatic properties. we have therefore studied the bronchodilatory and anticholinergic effects of this plant. the bronchodilatory effects of the aqueous extract (ae), macerated extract (me), essential oil (eo), and 4µm theophylline (t) in comparison with saline (s) were examined by their re...