We present the case of a 13-year-old child with nocturnal frontal lobe epilepsy (NFLE) related to a right cingulate gyrus cortical dysplasia, who also presented with psychogenic nonepileptic seizures (PNES) and interictal antisocial behavior. The association of drug-resistant epilepsy with behavioral disorders is well established, but the role of epilepsy surgery in these patients is still cont...

TRPC3 Mediates Hyperexcitability and Epileptiform Activity in Immature Cortex and 1 Experimental Cortical Dysplasia 2 3 Fu-Wen Zhou*, and Steven N. Roper 4 Departments of Neurosurgery and the McKnight Brain Institute, 5 University of Florida 6 7 Running Head: TRPC3 in cortical dysplasia 8 9 10 *Corresponding Author: 11 Fu-Wen Zhou, M.D., Ph.D. 12 Department of Neurosurgery 13 University of Flor...

Transcranial direct current stimulation (tDCS) is a reemerged noninvasive cerebral therapy used to treat patients with epilepsy, including focal cortical dysplasia, with controversial results. We present a case of a 28-year-old female with left frontal cortical dysplasia refractory to antiepileptic drugs, characterized by 10-15 daily right tonic hemi-body seizures. The patient received a total ...

PURPOSE To identify predictors of seizure recurrence following posterior quadrant epilepsy surgery. METHODS Between 1983 and 2008, 43 medically refractory epilepsy patients underwent posterior quadrant epilepsy surgery. Epilepsy surgery involved the occipital lobe in all cases; some cases also included resection of the adjacent parietal or temporal cortex. Using a logistic regression model, w...

BACKGROUND: Hip Dysplasia is a frequent orthopedic disease that is characterized by early joint sublux- ation. The DARthroplasty technique is a two-part process that involves applying bone graft to increase the femoral head coverage with a low morbidity rate and the long term is known results. OBJECTIVES: This study was aimed to investigate the radiograph...

Hippocampal sclerosis (HS) is one of the most common features of intractable temporal lobe epilepsy. Generally it can be identified through brain magnetic resonance imaging (MRI) with high degree of sensitivity and specificity. Typical brain MRI findings of HS are hippocampal atrophy with hyperintense signal confined to the lesion. On the other hand cortical dysplasia exhibits blurring of the g...

Cowden syndrome is a rare autosomal dominant disorder characterized by multiple hamartomas of the ectoderm and brain. A 36-year-old Japanese man presented with right facial seizure during sleep and was admitted to our hospital. He showed cobblestoning over the tongue and palmar pitting but no neurological abnormalities while he was not having a seizure. Brain magnetic resonance imaging showed f...

Fibrous dysplasia is an uncommon benign disease of the bone, with slow progression. Monostotic involvement of the paranasal sinuses is rare. We report a 54year-old woman who had complaints of facial asymmet r y, chronic sinusitis, recurrent headaches, and nasal obstruction for two years. Conventional radiography showed opacification and expansion of the maxillary sinus. Axial and coronal comput...

BACKGROUND AND PURPOSE Focal cortical dysplasia (FCD) covers a spectrum of conditions in which the neuropathologic and electroclinic presentations and the surgical outcomes vary. The aim of this study was to identify the MR features of histologic subtypes of FCD that would be useful for differential diagnosis. METHODS We reviewed the MR data of 49 patients treated surgically for intractable p...

Rasmussen's encephalitis is a well-established, albeit rare cause of medically intractable epilepsy. In a small number of Rasmussen's cases, a second pathology is identified, which independently can cause medically intractable seizures (dual pathology). This paper documents a case of a 13-year-old male who presented with medically intractable epilepsy. The patient underwent a series of surgical...