objective(s):intermittent hypoxia (ih), caused by obstructive sleep apnea (osa), could cause hippocampus or neuron damage through multiple signaling pathways, while the underlying mechanisms are still unclear. thus, the present study aimed to explore the effect of ih on the biological functions of microglia cells. materials and methods:cell proliferation of bv2 cells after exposure to ih were o...

Chronic lymphocytic leukemia (CLL), the most frequent type of leukemia in western countries, is characterized by the progressive accumulation in blood, bone marrow and lymphoid tissues of monoclonal B lymphocytes with a characteristic immunophenotype. Despite advances in therapy and improved outcome, in most instances CLL is an incurable disorder. Signaling via the B-cell receptor (BCR), the up...

In this paper, a new very fast fault simulation method to handle the X-fault model is proposed. The method is based on a two-phase procedure. In the first phase, a parallel exact critical path fault tracing is used to determine all the detected stuck-at faults in the circuit, and in the second phase a postprocess is launched which will determine the detectability of X-faults. Keywords-digital c...

The method for finding fuzzy optimal solution of fully fuzzy critical path (FFCP) problems i.e., critical path problems in which all the parameters are represented by fuzzy numbers, is at best scant; possibly non-existent. In this paper, a method is proposed to find the fuzzy optimal solution of FFCP problems, together with a new representation of triangular fuzzy numbers. This paper will show ...

Risk management is a process aimed at enhancement, developing the level of security in an organization. It gives the organization a broad view of the risks that can affect its productivity and performance, and enables it to make appropriate risk management decisions. This paper presents a new fuzzy method for measuring risk element criticality in a fuzzy project network. There have been several...

A novel technique to improve energy e ciency is disclosed. It relies on a fault-tolerance mechanism for timing constraints based on speculative execution technique. Since power reduces quadratically with supply voltage, supply voltage reduction can result in substantial power savings. However, it also causes larger gate delay, and thus clock must be slow down in order not to violate timing cons...

Software is a major expense for most organizations and is on the critical path to almost all organizational activities. Individual software development organizations in general strive to develop higher quality systems at a lower cost for both their internal and external customers. Yet the processes used to develop such software are still very primitive in the way that experience is incorporated...