A model of colour formation within human skin has been developed to aid the characterisation of pigmented skin lesions from their digitized colour images. The model is based on the Kublenka–Munk theory of scattering and absorption within inhomogeneous materials and the physics pertaining to their colour properties. By considering the skin to be a layered construction of such materials, the stra...

OBJECTIVE The aim of the present study was to evaluate the fluid shift in a simulated microgravity experiment and to test the use of thigh cuffs to help alleviate the problem. METHODS The change in skin thickness was assessed by a 20 MHz B-scan ultrasound device. This was performed on eight volunteers who underwent two successive 7-day periods of -6 degrees anti-orthostatic bed-rest, with or ...

BACKGROUND Quantification of drug uptake and clearance in the skin layers could provide better insight into the skin kinetics of dermatological formulations aimed for deeper skin tissues. This study assessed the skin kinetics of acyclovir in different skin layers following topical application on the abdominal region of Wistar rats. METHODS In vivo skin pharmacokinetics parameters were determi...

Skin applications of non-thermal atmospheric pressure plasma (NTAPP) have been at-tracting attention from medical and cosmetic aspects. The reactive species generated sources known to play important roles in the skin. For proper applications, it is essential know how they diffuse into In this study, penetration active NTAPP through a skin model was analyzed by UV absorption spectroscopy. diffus...

Diethylstilbestrol (DES) was injected in doses ranging from 600 micro g to 0.4 micrograms/kg body weight into mature male rats over a 3 wk period. Profound effects on skin morphology and on sterol content of skin were noted. The sebaceous glands atrophied and the epidermis lost granularity. The concentrations of all skin sterols, with the exception of cholesterol, were reduced. At a dose level ...

Abstract: Tolnaftate, an antifungal of thiocarbamate class, is used topically in 1% formulations. Its penetration into skin layers is a prerequisite for tolnaftate action against dermatophytes. The aim of this work was to optimize and validate a simple, rapid, accurate and reproducible procedure for tolnaftate assay in human skin samples and to apply this procedure for in vitro tolnaftate penet...

Sulfur mustard or mustard gas has been widely used as a chemical weapon in the first world war and Iraq-Iran war. It causes acute and chronic complications in lungs, eyes and skin. In skin, mustard is toxic, mutagenic, and carcinogenic via alkylation of cellular proteins in enzymes, cell membranes, cytoplasm and particularly cell nucleus as well as in DNA components of the epidermis, dermis and...

Non-thermal plasmas are gaseous mixtures of molecules, radicals, and excited species with a small proportion of ions and energetic electrons. Non-thermal plasmas can be generated with any high electro-magnetic field. We studied here the pathological effects, and in particular cell death, induced by nanosecond-pulsed high voltage generated plasmas homogeneously applied on cell cultures and nude ...

wound healing in the skin depends upon the availability of appropriate trace metals as enzyme cofactors and structural components in tissue repair. the present study is a part of a series of experimental investigations to examine the influence of bentonite on skin wound healing. surgically induced skin wounds in 48 young adult male rats were exposed topically to bentonite (12 round wound and 12...

OBJECTIVES To investigate the pathogenesis of pressure ulcers utilizing high-resolution ultrasound and to explore the utility of this technology for the detection of incipient pressure ulcers prior to visual clinical signs. DESIGN An observational prospective study comparing high-resolution ultrasound images obtained from 119 long-term-care facility residents determined to be at risk for pres...