By learning lessons from weed science we have adopted three approaches to make plants more effective in phytoremediation: (1) The application of functional genomics to identify key components involved in the detoxification of, or tolerance to, xenobiotics for use in subsequent genetic engineering/breeding programmes. (2) The rational metabolic engineering of plants through the use of forced evo...

Nasturtium (Tropaeolum majus L.) contains high concentrations of benzylglcosinolate. We found that a hydrolysis product of benzyl glucosinolate-the benzyl isothiocyanate (BITC)-modulates the intracellular localization of the transcription factor Forkhead box O 1 (FOXO1). FoxO transcription factors can antagonize insulin effects and trigger a variety of cellular processes involved in tumor suppr...

Corresponding Author: V. Fernández Laboratorio de Biología Celular y Molecular. Centro de Investigación Veterinaria de Tandil, Argentina Email: [email protected] Abstract: Fasciolosis, a parasitic zoonosis of intrahepatic location, is caused by the trematode Fasciola hepatica. Its control is mainly based on the use of the anthelminthic Triclabendazole (TCBZ). The indiscriminate use of t...

Anopheles sinensis is the most important vector of malaria in Southeast Asia, including China. Currently, the most effective measure to prevent malaria transmission relies on vector control through the use of insecticides, primarily pyrethroids. Extensive use of insecticides poses strong selection pressure on mosquito populations for resistance. Resistance to insecticides can arise due to mutat...

Triatomine insects are vectors of the protozoan Trypanosoma cruzi , causative agent Chagas disease. Although residual pyrethroid spraying has been a successful vector control strategy for many years, growing number pyrethroid-resistance foci is being documented, mainly in Triatoma infestans that led to failures elimination. Insecticide resistance multifactorial phenomenon often implies combinat...

BACKGROUND Alcohol-induced changes in thyroid function may contribute to the development of mood disorders such as depression and anxiety that almost invariably coexist in alcohol-dependent individuals. The aim of the present study was to investigate the severity of liver dysfunction and thyroid activity in correlation with anxiety and depressive-like symptomatology before and after a detoxific...

Background Endometriosis is one of the most commonly encountered benign problems in gynaecology. It is frequently associated with chronic pelvic pain, dysmenorrhoea, menorrhagia and dyspareunia, which lead to infertility. We determined the possible association between CYP1A1 MspI and GSTM1 null polymorphism in the pathogenesis of endometriosis. MaterialsAndMethods Ninety seven cases of endometr...

Ultraviolet irradiation directly affects the skin and promotes photoaging by causing depletion of antioxidative enzymes. We recently reported that M1/M2 macrophage ratio is altered in photo-aged skin. However, relationship between balance expression enzymes has not been fully investigated. Here, we show skewing related to reduction enzyme peroxiredoxin 4 (PRDX4) it may lead photoaging. performe...

The effect of exposure of Aedes aegypti larvae for 72h to sub-lethal concentrations of the herbicide glyphosate and the polycyclic aromatic hydrocarbon benzo[a]pyrene on their subsequent tolerance to the chemical insecticides imidacloprid, permethrin and propoxur, detoxification enzyme activities and transcription of detoxification genes was investigated. Bioassays revealed a significant increa...

Aryl hydrocarbon hydroxylase in mouse skin epidermis was inducible by topical applications of 1,2,5,6-dibenzanthracene (DBA), 7,12-dimethylbenz[a] anthracene (DMBA), and 5,6benzoflavone. 7,8-Benzoflavone given topically inhibited the enzyme activity; phénobarbitalgiven topically had little or no effect on this enzyme activity. 7,8-Benzoflavone given at the same time as DMBA inhibited the forma...