To better translate basic research findings into the clinic, we are moving away from the traditional one-gene-one-phenotype model towards the discovery of complex mechanisms. In this Editorial, the new Editor-in-Chief and Senior Editors of Disease Models & Mechanisms (DMM) discuss the role that the journal will play in this transition. DMM will continue to provide a platform for studies that br...

This paper provides the implementation mechanism of the pmipv6-based partially distributed mobility management (DMM) and performs extensive simulations under various traffic environments for verification and evaluation of the proposed scheme. The simulation results indicated that Mobility Anchor and Access Router (MAAR) could distribute and manage all IP data packet flow between a corresponding...

The potential of dimethyl ether (DME) and dimethoxymethane (DMM), representatives the attractive oxymethylene (OME) alternative fuel family, are explored here as reactivity enhancers for methane-fueled polygeneration processes. Typically, such processes that can flexibly generate power, heat, or chemicals, operate under fuel-rich conditions in gas turbines internal combustion engines. To provid...

An analytical method is presented to estimate the effects of structural disorder on the thermal boundary conductance TBC between two materials. The current method is an extension of the diffuse mismatch model DMM where the interface is modeled as a virtual crystal of finite thickness with properties derived from those of the constituent materials. Using this approximation, the TBC for a series ...

The recent article (Turalska et al., 2012) discusses the emergence of intelligence via criticality as a consequence of locality breakdown. Herein, we use criticality for the foundation of a novel generation of game theory making the local interaction between players yield long-range effects. We first establish that criticality is not confined to the Ising-like structure of the sociological mode...

Behavioral modeling languages are most useful if their behavior is specified formally such that it can e.g. be analyzed and executed automatically. Obviously, the quality of such behavior specifications is crucial. The rule-based semantics specification technique Dynamic Meta Modeling (DMM) honors this by using the approach of Test-driven Semantics Specification (TDSS), which makes sure that th...

Abstract We conducted the geochemical modeling of trace element contents for primary melts olivine-phyric rocks from Kamchatsky Mys. This reveals substantial chemical heterogeneity their source while average composition is close to enriched DMM (E-DMM). The estimation melting degree in range 9.1 ± 3.8% model modal batch 15.4 5.2% accumulated fractional melting, which slightly higher than primit...