Dynamic Meta Modeling (DMM) is a visual semantics specification technique targeted at languages based on a metamodel. A DMM specification consists of a runtime metamodel and operational rules which describe how instances of the runtime metamodel change over time. A known deficiency of the DMM approach is that it does not support the refinement of a DMM specification, e.g., in the case of defini...

BACKGROUND The signals that determine atherosclerosis-specific DNA methylation profiles are only partially known. We previously identified a 29-bp DNA motif (differential methylation motif [DMM]) proximal to CpG islands (CGIs) that undergo demethylation in advanced human atheromas. Those data hinted that the DMM docks modifiers of DNA methylation and transcription. METHODS AND RESULTS We soug...

In situ IR spectroscopy was used to observe the intermediates formed on zeolites FAU and MFI during the synthesis of methyl methoxyacetate (MMAc) via carbonylation of dimethoxymethane (DMM) and the disproportionation of DMM to dimethyl ether (DME) and methyl formate (MF). Both reactions are initiated by the reaction of DMM with the Brønsted acid protons of the zeolite to form methanol and metho...

This paper presents the results of a simulation study of a typical flexible manufacturing system (FMS) that has routing flexibility. The objective in this study is to test the effectiveness of the modified dissimilarity maximization method (modified DMM) for real time FMS scheduling. modified DMM method is an improvement of the DMM method. Modified DMM method is an alternative process plan sele...

Desmoplastic malignant melanoma (DMM) is an extremely rare subtype of cutaneous melanoma that has diverse clinical presentations. We describe the unique case of a 57-year-old man presenting with empyema secondary to vascular occlusion from metastatic DMM. Only two other cases of DMM presenting as a lung mass have been previously reported in the literature. This report highlights potential insid...

Transposable elements are common in genomes and must be controlled. Many organisms use DNA methylation to silence such selfish DNA, but the mechanisms that restrict the methylation to appropriate regions are largely unknown. We identified a JmjC domain protein in Neurospora, DNA METHYLATION MODULATOR-1 (DMM-1), that prevents aberrant spreading of DNA and histone H3K9 methylation from inactivate...

Diffuse malignant mesothelioma (DMM) is one of the prognostically most discouraging cancers with median survivals of only 12-22 months. Due to its insidious onset and delayed detection, DMM is often at an advanced stage at diagnosis and is considered incurable. Combined chemo- and radiotherapy followed by surgery only marginally affect outcome at the cost of significant morbidity. Because of th...

Submillimeter-scale dispersion micromanagement (DMM) is discussed and used to generate coherent and stable femtosecond visible pulses (bandwidth up to 50 nm and scalable center wavelength in the range of 385–625 nm) in tapered holey fibers as short as 10 mm. The longitudinal variation of the phase-matching conditions for Cherenkov radiation and four-wave mixing explains the results well. We com...

Diffuse malignant mesothelioma (DMM) is a tumour which arises from cells of mesodermal origin layering the surface of the thoracic and abdominal serosal cavities of the body. All epidemiological studies indicate that its incidence is increasing in males in industrialized countries, obviously in direct relation with past occupational exposure to asbestos [1-3]. However, it is now well demonstrat...