BACKGROUND The HIV epidemic in the United States (US) disproportionately affects gay, bisexual, and other men who have sex with men (MSM). Pre-exposure prophylaxis (PrEP) using co-formulated tenofovir disoproxil fumarate (TDF) and emtricitabine (FTC) has demonstrated high efficacy in reducing HIV incidence among MSM. However, low adherence was reported in major efficacy trials and may present a...

BACKGROUND This was a systematic review of the literature in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. Evidence mapping was used to reveal the effect of drug reminder packaging on medication adherence, to identify research gaps and to make suggestions for future research. METHODS PubMed, Embase, CINAHL and PsycINFO were searched...

OBJECTIVE Cross-sectional survey research aimed at studying predictive factors of antiretroviral (ARV) drug adherence among people living with HIV/AIDS (PWHA) who attended Tawan Mai, an outpatient clinic, Taksin Hospital, Bangkok. MATERIAL AND METHOD The sample group was 230 PWHA. A random sampling technique was used to select the sample. Data were collected by interview questionnaire between...

INTRODUCTION AND OBJECTIVE Non-adherence to drug treatment is a major health problem. In Europe, it has been estimated that 9% of cardiovascular events can be attributed to non-adherence. The complexity of dosing regimens is one of the factors identified as contributing to non-adherence. In this systematic review we aimed to assess the impact of dosing frequency on adherence to drug treatment i...

INTRODUCTION Non-adherence to medical regimen has remained a challenge to the medical profession as well as to social sciences. To achieve positive results, the factors negatively impacting patient adherence to medical regimens (i.e., diet, drug and exercise regimen) must be scrutinized in detail. The objective of this research was to explore the relationship between cognitive appraisal and adh...

Aims: Dual platelet inhibition using anti-P2Y12 drugs and aspirin is the standard of care in patients after percutaneous coronary interventions (PCI). Prasugrel and ticagrelor have been shown to be more potent than clopidogrel with less high on-treatment platelet reactivity. Whether differences in long-term adherence to these drugs can partly explain different antiplatelet efficacy has not been...

We develop a stochastic HIV model by integrating drug adherence into pharmacokinetic and coupling pharmacodynamic with viral dynamic model. Numerical simulations show that the proposed can generate blips, which have been observed in patients receiving suppressive antiretroviral therapy. calculate probability density function of infected CD4+ T cells developing generalized evolution equation. fi...

BACKGROUND Little is known about how Medicare Part D affects the medication refill adherence for cardiovascular and diabetes medications, particularly among beneficiaries without prior drug coverage. OBJECTIVES To evaluate Medicare Part D's effect on medication adherence among beneficiaries with hyperlipidemia, hypertension, and/or diabetes enrolled in Medicare Advantage products. RESEARCH ...