Objective(s): Ketotifen fumarate (KF) is a selective and noncompetitive histamine antagonist (H1-receptor) that is used topically in the treatment of allergic conditions of rhinitis and conjunctivitis. The aim of this study was to formulate and improve an ophthalmic delivery system of KF.Ocular nanoparticles were prepared with the objective of reducing the frequency of administration and obtain...

In the present study, a nanoporous metal organic framework (MOF) based on iron metal and amino terephthalate ligand MIL-101-NH2-Fe has been used as a carrier for loading and in vitro release of 5-flurouracil (5-FU) anticancer drug. The 5-FU drug loaded MOF was 13 wt % by using thermogravimetric analysis (TGA). The 5-FU release was monitored under physiological condition at 37°C, pH 7.4 in simul...

Abstract The main aim of this study was to prepare and evaluate the extended - release system of an anxiolytic substance. Alprazolam is a short-acting benzodiazepine with general properties similar to those of diazepam. Our studies focused on the development of extended drug delivery system based on Hydroxy Propyl Methyl Cellulose (HPMC 4000cps) as retard agent and polyvinylpyrrolidone (PVP k30...

In the long-term management of ulcerative colitis patients, repeat dosing maybe required. Since 5-ASA is largely absorbed from the upper intestine, selective delivery of drugs into the colon may be regarded as a better method of drug delivery with fewer side effects and a higher efficacy. The aim of this study was to prepare and evaluate a double coated multiparticulate system for 5-ASA deliver...

the influence of various polymers on the release rate of lithium carbonate from matrix-type tablets was investigated in an attempt to formulate a sustained release solid dosage form. for this purpose, tablets containing 450 mg of lithium carbonate along with various amounts of carbopol 934p, 971p, 974p, pemulen and eudragit rlpo as retarding agents and inactive ingredients (e.g. pvp, avicel or ...

frequent dosing of the potent anti-androgen, flutamide, is necessary to reach a therapeutic level for the treatment of prostatic carcinoma. sustained delivery of the drug could reduce the adverse effects such as gastrointestinal disorders and improve patient compliance. in the present study sustained-release matrix tablets of flutamide were prepared by direct compression method using different ...

the present study is aimed at the overall improvement in the efficacy, reduced toxicity and enhancement of therapeutic index of cisplatin. nanocapsules of cisplatin containing ethylcellulose have been prepared using solvent evaporation technique under ambient conditions. the prepared nanocapsules were used for controlled drug release of anticancer agents with gold and iron oxide nanoparticles. ...

a topical o/w cream containing tretinoin microspheres was prepared. gelatin microspheres of tretinoin were prepared using coacervation method. these microspheres contained about 50% w/w tretinoin. the particle size range of microspheres was between 90-150 m m. in vitro drug release from microspheres and a cream formulation was studied. it was shown that drug release from microspheres followed h...

the present work focuses on preparation and characterization of erythromycin loaded gelatin nanoparticles through nanoprecipitation method. the procedure consists of the increase of the aqueous gelatin solution to the non-solvent phase containing lutherol f127. three different measures of cross-linker and polymer concentration were also examined, and the optimum concentration was found. the mor...

objective(s): in this work, electrospun nanofibers were explored as drug delivery vehicles using tetracycline as a model drug.  nanocomposite fibers including chitosan (cs)/poly (ethylene oxide) (peo) and antibiotic were successfully prepared using electrospinning. cs blended with peo considering a weight ratio of (90/10), and then, nanofibrous samples were successfully electrospun from their a...