The microsomal triglyceride transfer protein (MTP) is required for the assembly and secretion of apolipoprotein B (apoB)-containing lipoproteins from liver and intestine. We set out to study the phenotypic modulation of all common genetic variants in the MTP gene. In addition, we aimed at characterizing the association between the various polymorphisms. A total of 564 healthy men were genotyped...

Molecular anthropology the study of human genetic polymorphisms is fast and ever-growing branch of anthropology that holds a great promise for both past and future. Indian subcontinent with its remarkable environmental, geographical, morphological, genetic, cultural and linguistic diversity provides immense promise for anthropological investigations to address origins of its people, population ...

background: the apolipoprotein e (apoe) polymorphism is known to affect various neurologic disorders with different effects on the immune system and cns repair. however, previous studies on possible modulation of the clinical course of multiple sclerosis (ms) by apoe polymorphism have been inconsistent.   objective: to clarify the issue for ms patients' management and future research.   methods...

BACKGROUND Surfactant proteins (SP) are important for the innate host defence and essential for a physiological lung function. Several linkage and association studies have investigated the genes coding for different surfactant proteins in the context of pulmonary diseases such as chronic obstructive pulmonary disease or respiratory distress syndrome of preterm infants. In this study we tested w...

Age-related macular degeneration (AMD) is the leading cause of blindness in the elderly in the developed world. Numerous genetic factors contribute to the development of the multifactorial disease. We performed a case-control study to assess the risk conferred by known and candidate genetic polymorphisms on the development of AMD. We searched for genetic interactions and for differences in dry ...

OBJECTIVE Norepinephrine is an important chemical messenger that is involved in mood and stress in humans, and is reabsorbed by the norepinephrine transporter (NET). According to Cloninger's theory, the noradrenergic system mediates the personality trait of reward dependence. Thus far, although association studies on NET gene polymorphisms and Cloninger's personality traits have been reported, ...

Elevated levels of transforming growth factor-β1 (TGF-β1) and its positive correlation with Foxp3 expression in hepatitis E patients have indicated involvement of TGF-β1 in hepatitis E pathogenesis. The current study determined polymorphisms in TGF-β1 gene, plasma TGF-β1 levels and T effector (Teff) cell proliferation and explored their association in a case control study. Polymorphisms in thre...

Grazing endophyte-infected tall fescue (E+) negatively impacts cattle feed intake and growth negatively (Crawford et al., 1989). However, the interaction between environmental factors and animal genetics may influence important cattle growth measurements before and after the weaning process (Phillips et al, 2001). For example, polymorphisms (mutations) in the prolactin and cytochrome P450 genes...

To study the regulation of plasma low density lipoprotein (LDL) cholesterol in postmenopausal women (n = 79), fasting plasma lipids and lipoproteins, the fractional catabolic rate (FCR) and production rate for LDL apolipoprotein B (apo B), cholesterol absorption, apolipoprotein E phenotype and polymorphisms of the apo B and 7alpha-hydroxylase genes were determined. The level of LDL cholesterol ...

Allorecognition is the capability of an organism to recognize its own or related tissues. The colonial ascidian Botryllus schlosseri, which comprises five genetically distinct and divergent species (Clades A-E), contains two adjacent genes that control allorecognition: fuhcsec and fuhctm. These genes have been characterized extensively in Clade A and are highly polymorphic. Using alleles from 1...