Background: The role of apolipoprotien E polymorphisms do not diagnostic correctly in recurrent pregnancy loss etiology but Apo E has been shown to play an important role in lipid metabolism in pregnancy. We evaluated these polymorphisms in Iranian women with unexplained recurrent pregnancy loss. Materials and Methods: 5 ml Blood were sampling from 81 women with a history of two or more consecu...

background: in the visceral leishmaniasis (vl), parasites reside in reticuluendothelial system, mainly in macrophages. endothelial selectin (e-selectin) might play an important role in leukocyte-endothelium interactions and inflammatory cell recruitment. the aim of this study was determining e-selectin level and its polymorphism in three groups, patients, seroposi­tive and healthy individuals. ...

tumor necrosis factor alpha-inducible protein 3 (tnfaip3) gene polymorphisms have been reported to be associated with the susceptibility to several immune-related diseases. here we investigated the effect of tnfaip3 gene polymorphisms on the risk of allergic rhinitis (ar) in a chinese han population. the case-control study included 540 ar patients and 524 healthy controls. genotyping for tnfaip...

the  non-classical mhc  class-i mainly involves in the  regulation of  innate  immune responses where hla-e  plays a significant role in the cell identification by natural killer cells. hla-e is a main regulatory ligand for natural killer cells and given the importance of these effector cells in hematopoietic stem cell transplantation, we investigated the effect of hla-e polymorphisms on post-h...

Background: During pregnancy, the maternal immune system is in close contact with cells and tissue from the semiallogenic fetus .The human leucocyte antigen (HLA) class Ib molecules, HLA-E, -F and -G, are expressed at the materno-fetal interface. Because of the apparent immunoregulatory functions of these proteins, they may be involved in successful acceptance of the semi-allogenic fetus during...

Introduction: E-selectin and ICAM-1 are cellular adhesion molecules that play important roles in the pathogenesis of Sickle Cell Disease (SCD), especially vaso-occlusion process. Numerous studies reported single nucleotide polymorphisms genes may be associated with clinical expression several diseases. However, no evidence exists regarding association SCD. Objectives: Investigate E-selectins (S...

Background: During pregnancy, the maternal immune system is in close contact with cells and tissue from the semiallogenic fetus .The Human Leucocyte Antigen (HLA) class Ib molecules, HLA-E, -F and -G, are expressed at the materno-fetal interface. Because of the apparent immunoregulatory functions of these proteins, they may be involved in successful acceptance of the semi-allogenic fetus during...

conclusions the current meta-analysis showed an association between frequency of gg genotype of pnpla3 and the risk of development of chc in various populations throughout the world. results five hospital-based case-control studies were included in the final analysis. the overall frequency of pnpla3 gene polymorphisms was 20.4% (205/1005) in chc and 10.23% (53/518) in controls. the summary odds...