Cholangiocarcinoma (CCA) is a fatal disease that is typically diagnosed late and treated ineffectively. As the morbidity and mortality rates for CCA rise markedly, patietns with CCA currently have a poor prognosis. However, if it were possible to diagnose CCA early while effective treat methods are available, CCA patients would achieve a better quality of life. Therefore, preventing the process...

We have read with much interest an article recently published by Ekwueme et al. about the impact of the National Breast and Cervical Cancer Early Detection Program on cervical cancer mortality among uninsured low-income women in the U.S. Cervical cancer is a relevant issue in Peru, owing to its high incidence and mortality rate when compared with other countries. Despite being a fully preventab...

Successful deployment of early detection technologies to population-based screening for colon, cervix, and, arguably, breast cancer has been responsible for recently observed reductions in disease-associated mortalities from these common malignancies, which are uniformly fatal in their advanced stages. With the advent of highthroughput technologies capable of interrogating genes, proteins, and ...

Invasive aspergillosis (IA) are a major complication in immunocompromized patients where can be serious and rapidly fatal. Early diagnosis and early appropriate antifungal treatment is important in reducing mortality and morbidity. But despite many efforts to develop detection methods, the diagnosis of IA still remains challenging and current conventional methods are limited for adequate diagno...

Acromegaly is a disease associated with increased morbidity and reduced life expectancy. Because of its insidious character and its non-recognition, the diagnosis is often made with delay, which, along with the complications related to GH/IGF-I excess, determines high morbidity and mortality. However, an early diagnosis and an effective treatment reduce the morbidity and normalize the mortality...

Recommendations against screening for lung cancer were based on the lack of a reduction in mortality of the screened group as compared with the control group in randomized control trials. These results were interpreted as showing that early detection of lung cancer as a result of screening did not decrease the mortality rate compared with detection after presentation of symptoms for the populat...

BACKGROUND Cervical cancer is the leading cause of cancer related deaths among women in Nepal. The long symptom to diagnosis interval means that women have advanced disease at presentation. The aim of this study was to identify, estimate and describe the extent of different delays in diagnosis of cervical cancer in Nepal. METHODS A cross-sectional descriptive study was conducted in two tertia...

the empiric antibiotic therapy can result in antibiotic overuse, development of bacterial resistance and increasing costs in critically ill patients. the aim of the present study was to evaluate the effect of procalcitonin (pct) guide treatment on antibiotic use and clinical outcomes of patients admitted to intensive care unit (icu) with systemic inflammatory response syndrome (sirs).  a total ...

b a ckground: development of insecticide resistance occurred due to the continuous and misuse of synthetic insecti- cides therefore, the recent study was conducted to explore eco-friendly plant extracts that have some potential to sup- press mosquito larval population. m e t hods: who recommended mosquito larval bioassay method for insecticide was used while for the analysis of cit- rus oils fo...