بدلی , حمید

دانشگاه علوم پزشکی مازندران

[ 1 ] - رمزینه‌گذاری داکسی ریبونوکلئیک اسید (Barcoding DNA): افقی جدید در شناسایی مولکولی قارچ‌های پاتوژن (مقاله مروری)

چکیده تعداد گونه‌های قارچی موجود حدود 5/1 میلیون عدد برآورد شده است که تا امروز کمتر از 10 درصد آنها توصیف شده‌اند. با پیشرفت‌های اخیر در زیست‌شناسی مولکولی و توسعه فناوری‌هایی مثل توالی‌یابی ژنی و ژنومی، کشف و شناسایی گونه‌های جدید در گروه‌های مختلف موجودات زنده به‌ویژه قارچ‌ها روند افزایشی به خود گرفته است. با توجه به ناکارآمدی روش‌های مبتنی بر ریخت‌شناسی برای شناسایی گونه‌های قارچی، استفاده...

[ 2 ] - مروری بر تکنیک های مولکولی در شناسایی سریع موتاسیون های منجر به مقاومت آزولی در قارچ های پاتوژن شایع

Invasive candidiasis and aspergillosis are amongst major medical concerns with high mortality among immunocompromised patients. Management of these infections is dependent on early and efficient antifungal therapy, as well as drug resistance monitoring. Decreased sensitivity of these pathogens to antifungal drugs during recent decades calls for rapid detection/identification of drug resistance ...

[ 3 ] - عفونت کاندیدایی دستگاه ادراری؛ پروتکل درمانی

Background and purpose: The choice of antifungal agent in treatment of Candida urinary tract infections (CUTI) is dependent on the site of infection, the underlying disease of the patient, and the pharmacokinetics/pharmacodynamics (PK/PD) of the agent. This study aimed to perform a review of antifungal therapy for CUTI. Materials and methods: Data was obtained by a search for full-text artic...

[ 4 ] - مروری بر کاربرد روش‌های تایپینگ مولکولی در گونه های آسپرژیلوس

Conidia of Aspergillus species are widely distributed and ubiquitous in outdoor and hospital environments. There are high numbers of patients with weakened immune systems, therefore Aspergillus infections are increasing in hospitals. Molecular typing of Aspergillus strains obtained from patients and their environment is an important tool for epidemiological and public health studies. Fingerprin...

[ 5 ] - نقش رسپتورهای شناساگر الگو (PRR) در ابتلا به عفونت های کاندیدایی در انسان

Candida species are medically significant yeast that can cause different infection ranging from mild mucosal to disseminated infection. Invasive and sever mucosal infections are often life threatening disorders, especially in immunocompromised hosts due to immunodeficiency either in adaptive or innate immunity which are susceptible to candidiasis. Nevertheless, not all of them are susceptible t...

[ 6 ] - تعیین توالی در چند ناحیه ژنی (MLST): یک روش تایپینگ مولکولی با قدرت تمایز بسیار بالا جهت شناسایی گونه‌های کاندیدا آلبیکنس در مطالعات اپیدمیولوژیکی

Candida spp. are ubiquitous yeasts commonly. Those are commensally and opportunist pathogens in humans. Candidiasis in immunocompromised patients and patients with severe underlying diseases or critical illnesses need aggressive diagnosis or treatment procedures. Candida albicans (C. albicans) is the most frequently isolated species. For prevention of nosocomial infections caused by C. albicans...

[ 7 ] - کلونیزاسیون عوامل قارچی در بیماران مبتلا به سیستیک فیبروزیس

Due to the predisposing conditions in patients with cystic fibrosis (CF) caused by defective mucociliary clearance facilitates of colonization and invasion with bacteria and fungal species has dramatically increased. In different studies many opportunistic fungi such as Candida and Aspergillus species have been frequently isolated from the respiratory tract of patient suffering from cystic fibr...

[ 8 ] - تنوع ژنتیکی و اکولوژیکی قارچ‌های بی‌هوازی شکمبه حیوانات نشخوارکننده: گذشته، حال و آینده

سابقه و هدف: قارچ‌های شکمبه برای اولین بار در سال 1910 توجه قارچ‌شناسان را به خود جلب کردند. بعدها به دلیل محتوای کیتین در دیواره سلولی، این قارچ‌ها در گروه قارچ های حقیقی طبقه بندی شدند و با عنوان نئوکالیماستیکس فرونتالیس نام‌گذاری گردیدند. امروزه بر اساس ویژگی های ریخت‌شناختی مانند تعداد تاژک در زئوسپور، ریزومیسلیوم، شکل اسپورانژ، فراساختار زئوسپور و داده‌های توالی‌های نوکلئوتیدی شش جنس از ای...

[ 9 ] - Microsatellite Genotyping of Candida parapsilosis Clinical Isolates

Background and Purpose: Candida parapsilosis is a predominant species found in nosocomial infection, particularly in hospitalized patients. The molecular epidemiology of the clinical strains of this species has not been well studied. The present study was performed with the aim of investigating the microsatellite genotyping of Candida parapsilosis among the Iranian clinical isolates. Materials...

[ 10 ] - Is human dectin-1 Y238X gene polymorphism related to susceptibility to recurrent vulvovaginal candidiasis?

Background and Purpose: Vulvovaginal candidiasis is a frequent disease affecting approximately more than %75 of all childbearing women at least once in their lifetime by overgrowth of opportunistic Candida species. Recurrent vulvovaginal candidiasis (RVVC) is common in otherwise healthy individuals. Several risk factors were reported to contribute to RVVC susceptibility. A polymorphism in Decti...

[ 11 ] - In vitro activity of five antifungal agents against Candida albicans isolates, Sari, Iran

Background and Purpose: Candida albicans is the most common causative agent of candidiasis. Candidiasis management is dependent on the immune status of the host, severity of disease, and the choice of antifungal drug. Antifungals, specifically triazoles, are widely administered for the treatment of invasive fungal infections. Herein, we aimed to evaluate the in vitro susceptibility of C. alb...

[ 12 ] - Susceptibility pattern of Candida albicans isolated from Iranian patients to antifungal agents

Background and Purpose: Candidiasis is a major fungal infection, and Candida albicans is the major cause of infections in humans. The Clinical and Laboratory Standards Institute (CLSI) developed new breakpoints for antifungal agents against C. albicans. In this multi-center study, we aimed to determine the drug susceptibility profile of C. albicans, isolated from Iranian population according...

[ 13 ] - Aspergillus colonization in patients with chronic obstructive pulmonary disease

Background and Purpose: Chronic obstructive pulmonary disease (COPD) has been recognized as a risk factor for invasive aspergillosis. Airway colonization by Aspergillus species is a common feature of chronic pulmonary diseases. Nowadays, the incidence of COPD has increased in critically ill patients. The aim of the present study was to isolate and identify Aspergillus colonies in the respirator...

[ 14 ] - Pneumocystis jirovecii colonization in Chronic Obstructive Pulmonary Disease (COPD)

Chronic obstructive pulmonary disease (COPD) is associated with a chronic inflammatory response in airways and lung parenchyma that results in significant morbidity and mortality worldwide. Cigarette smoking considered as an important risk factor plays a role in pathogenesis of disease. Pneumocystis jirovecii is an atypical opportunistic fungus that causes pneumonia in immunosuppressed host, al...

[ 15 ] - Molecular approaches to diagnosis of invasive aspergillosis what we know and what we do not know.

Invasive aspergillosis (IA) are a major complication in immunocompromized patients where can be serious and rapidly fatal. Early diagnosis and early appropriate antifungal treatment is important in reducing mortality and morbidity. But despite many efforts to develop detection methods, the diagnosis of IA still remains challenging and current conventional methods are limited for adequate diagno...