Objective(s): Weight gain and metabolic disturbances such as dyslipidemia, are frequent side effects of second-generation antipsychotics, including olanzapine. This study examined the metabolic effects of chronic olanzapine exposure. In addition, we investigated the hepatic fatty acid effects of olanzapine in female C57BL/6J mice fed a normal diet.Materials and Methods: Female C57BL/6J mice ora...

pcos (polycystic ovarian syndrome) is associated with insulin resistance, obesity and disorders of lipid metabolism as well as infertility. fenugreek seeds extract is successfully used in lowering blood glucose. metformin has also the same effect but in a different way. the aim of this study was the assessment of fenugreek effects on insulin resistance in women with pcos.this was a prospective ...

context since 2006 a relevant number of therapeutical algorithms for the management of type 2 diabetes have been proposed, generating a lively debate in the scientific community, particularly on the ideal timing for introduction of insulin therapy and on which drug should be preferred as add-on therapy in patients failing to metformin. at the moment, there is no real consensus. the aim of the p...

Objective(s): Systemic and intracerebroventricular (ICV) injection of insulin possess analgesic effects. The raphe magnus nucleus (RMN) is part of the endogenous analgesia system. The objective of the present study was to evaluate the effects of ICV injection of insulin on the levels of monoamines and their related metabolites in the RMN during the formalin test in non...

background a fall in plasma concentration of energy status related hormones (leptin, insulin-like growth factor-1 (igf-1) and insulin) and body energy expenditure occurs in response to short term fasting. nevertheless, the relations of the fasting-induced changes in energy related hormones and metabolites with fasting energy expenditure (fee) under extended fasting condition have received littl...

background: omega 3 and vitamin e are two critical nutrients which include beneficial effects in coronary artery disease (cad). the aim of this study was to assess the effects of omega 3 alone supplementation or in combination with vitamin e on serum glucose and lipid levels and insulin resistance in cad patients. methods: participants of this clinical trial included 60 male patients with cad w...

garlic (allium sativum l., alliaceae), persian shallot (allium ascalonicum l., alliaceae ) and sage (salvia officinalis l., lamiaceae) are believed to have hypoglycemic properties and have been used traditionally as antidiabetic herbal medicines in iran. in this study, diabetes was induced by subcutaneous injection of alloxan monohydrate (100 mg kg−1) to male wistar rats. antidiabetic effects of...