Fifty 12,13-epoxytrichothecenes have been reported in the literature; of these diacetoxyscirpenol, T-2 toxin, nivalenol and vomitoxin have been naturally occurring in cereal grains throughout the world. Vomitoxin is produced in ears of corn prior to harvest when wet, cool weather precedes which favours Gibberella zeae growth. This type of infected corn, which often contains vomitoxin, is associ...

The medicinal value of cannabis (marijuana) is well documented in the medical literature. Cannabinoids, the active ingredients in cannabis, have many distinct pharmacological properties. These include analgesic, anti-emetic, anti-oxidative, neuroprotective and anti-inflammatory activity, as well as modulation of glial cells and tumor growth regulation. Concurrent with all these advances in the ...

Palonosetron (Aloxi(®), Onicit(®), Paloxi(®)) is a second-generation 5-HT(3) receptor antagonist (RA) with an extended half-life of ~40 hours and high binding affinity for the 5-HT₃ receptor that is markedly different from other 5-HT(3) RAs. Phase III trials demonstrate that a single dose of palonosetron compared with traditional 5-HT₃ RAs is more effective in preventing chemotherapy-induced na...

Several nonlethal methods have been developed to determine the stomach contents of fish, including gastroscopes, tubes, stomach suction, stomach flushing, emetics, forceps, and chronic fistulas. By reviewing the literature on this subject, we found that the effectiveness (ability to remove all stomach contents) of the different methods depends on size, age, species of fish, and the size of the ...

A liquid-chromatographic assay of 5-fluorouracil in plasma is described. Advantages of this procedure over gas chromatography are the simpler extraction procedure, elimination of the need for a derivitization step with silylating agents, and a 20-fold greater sensitivity. The minimum detectable concentration of 5-fluorouracil in plasma is 25 microgram/L. The enhanced sensitivity enabled measure...

The diagnosis and management of acute poisoning episodes in adolescents and young adults with anorexia nervosa are complicated by their underlying psychopathologic conditions. We investigated 23 consecutive cases of poisoning in 21 patients with anorexia nervosa reported to the Massachusetts Poison Center, Boston, during a 13-month period. All were intentional self-poisonings. Agents involved m...

The effect of cannabinoids on motion-induced emesis is unknown. The present study investigated the action of phytocannabinoids against motion-induced emesis in Suncus murinus. Suncus murinus were injected intraperitoneally with either cannabidiol (CBD) (0.5, 1, 2, 5, 10, 20 and 40 mg/kg), Delta(9)-tetrahydrocannabinol (Delta(9)-THC; 0.5, 3, 5 and 10 mg/kg) or vehicle 45 min. before exposure to ...

A new efficient method for the direct amidation of d-lysergic acid was used to prepare a variety of lysergamides. A pharmacological evaluation of these compounds, their diand tetrahydro derivatives, and derivatives bearing substituents in the indole portion of the molecule showed that, in general, only 9,lOdihydrolysergamides of primary amines possess activity comparable to the potent emetic ac...

Prashant Tiwari*, Bimlesh Kumar, Mandeep Kaur, Gurpreet Kaur, Harleen Kaur Plants are a source of large amount of drugs comprising to different groups such as antispasmodics, emetics, anti-cancer, antimicrobials etc. A large number of the plants are claimed to possess the antibiotic properties in the traditional system and are also used extensively by the tribal people worldwide. It is now beli...