Nausea and vomiting are major concerns for patients who have to receive chemotherapy for an underlying malignancy. In this review, these concerns faced by patients receiving chemotherapy are presented along with discussion of the mechanisms of chemotherapy induced nausea and vomiting. Major targets of the 5HT3 antagonists, the NK1 antagonists and the dopamine antagonists are discussed along wit...

Methotrexate (MTX) is an effective, relatively safe, and low-cost treatment for children with JIA, but its use is often limited by the occurrence of so called intolerance in a significant number of patients [1, 2]. Many JIA patients receive anti-emetics as a co-medication to prevent or treat MTXintolerance. In a recent review in this journal Falvey et al. concluded: “Co-medication with anti-eme...