The paper discusses diverse aspects of the concept epithelial-mesenchymal transition and compares basics this with classical concepts tissue biology. idea was first suggested by Elizabeth Hay (1927–2007) in 1968 based on analysis tridermogenesis development growth avian embryo. In late 80 s – early 90 twentieth century, epithelial–mesenchymal won supporters-pathomorphologists our country who ap...

Background and Aims: Ovarian cancer is one of most common causes of cancer related women's mortalities. Human papilloma virus is a known factor concerning cervical cancer but its role in causing ovarian cancer is not yet verified. A few studies also identified HPV DNA in ovarian carcinoma tissues. However, some studies did not detect HPV DNA in ovarian carcinoma tissues. In this articl...

Background: Chemotherapy or irradiation is associated with impaired fertility. The aim of this study was to investigate the possible protective role of testosterone enanthate (TE) on the proliferative activity, plasma testosterone level and morphometry of epithelial cells of seminal vesicles in busulfan-induced spermiotoxicity. Materials and Methods: Sprague- Dawley rats were divided into 4 gro...

    Background: Azo is a synthetic dye used in batik industries. It can be toxic to the tissue when exposed via inhalation, swallowing, or direct contact. Expression of cytokeratin will change in hyperplastic and cancer of the oral mucosa. Expression of Cytokeratin 8, 18, 19 is strong in the epithelial cells that undergo excessive hyperproliferation and oral mucosal changes in le...

Objective: Helicobacter pylori has a well-established role in the development of gastric cancer. In vitro studies reveal increased proliferation of the gastric mucosa in the presence of H. pylori infection. It has been also shown that production of some cytokines, such as interleukin-1 beta (IL-1b) is in...

Background: In apoptosis is physiological cell death which eliminates injured and old cells. Any disruption in apoptosis, leads to disease. Resveratrol is a natural polyphenol with estrogen-like, antioxidant and antiinflammatory properties; also it showed cell prolifratory and inhibitory effect. The aim of present study was to determine resveratrol effect on apoptosis of human endometrial epith...

Focal epithelial hyperplasia (FEH) or Heck’s disease is a rare viral infection of the oral mucosa caused by human papilloma virus especially subtypes 13 or 32. The frequency of this disease varies widely from one geographic region and ethnic groups to another. This paper reports an Iranian case of extensive focal epithelial hyperplasia. A 35-year-old man with FEH is described, in whom the lesio...

Background: Chlamydia (C.) trachomatis is an obligate intracellular gram-negative pathogen affecting over 600 million people worldwide with 92 million new cases occurring globally each year. Genital C. trachomatis infection has been recognized as the most common cause of pelvic inflammatory disease leading to severe tubal damage, ectopic pregnancy, hydrosalpinx and infertility. However, the mec...

conclusions this study showed that the frequency of bilin was low among iranian patients with psc. high bilirubin and ca19-9 can be predictors of the development of bile duct epithelial changes in patients with psc. background primary sclerosing cholangitis (psc) as one of the most common chronic cholestatic liver diseases is a main predisposing factor for the development of cholangiocarcinoma ...