We report significant failure rates (28%, 95% confidence interval 15%-45%) after administering 1 g azithromycin to men with Mycoplasma genitalium-positive nongonococcal urethritis. In vitro evidence supported reduced susceptibility of M. genitalium to macrolides. Moxifloxacin administration resulted in rapid symptom resolution and eradication of infection in all cases. These findings have impli...

malaria has always been regarded as one of the most important health problems with which iran is faced. most parts of the country, especially densely populated areas, were known as malarious areas. records of 1947 show that 25% of cases referred to health centers and dispensaries of the ministry of health were due to malaria in khuzestan and caspian sea areas. the mortality rate of malaria in t...

helicobacter pylori is an important human pathogen and a gram-negative, spiral shaped and microaerophilic bacteria with persistence colonization in gastric mucosa, causes gastroduodenal inflammation and destruction, resulting in diseases such as duodenal ulcer disease, gastric ulcer disease. when h.pylori discovered by warren and marshall, effective therapy developed for this infection and resu...

Background: The rate of Helicobacter pylori (H.pylori) eradication in dyspeptic patients using bismuth- based triple therapy is low due to bacterial that are resistant to antibiotics. The results of recent studies regarding levofloxacin have been encouraging, but the high cost of treatment prevents its routine administration. We, therefore, performed the present double-blind clinical trial to c...

background: furazolidone has been used as an alternative for clarithromycin or metronidazole in helicobacterpylori ( h . pylori ) eradication regimens.  in iran, 14-day furazolidone-containing quadruple regimens have shown promising eradication rates, but short-course, low dose therapies are always attractive. therefore, we designed a study to compare the efficacy of two 10-day triple regimens ...

BACKGROUND Rifabutin has been known to be effective in multidrug-resistant Helicobacter pylori-harboring patients undergoing treatment failure for H. pylori infection. AIM To evaluate the efficacy of 7-day treatment regimen consisting rifabutin daily but increasing the dose of amoxicillin and lansoprazole in patients who have failed first and second eradication and to assess the side effect p...

BACKGROUND AND AIMS Quadruple therapy is recommended as second-line treatment for Helicobacter pylori eradication failure. However, high cost, multiple side effects, and low adherence rates are major drawbacks to its routine use. Our aim was to compare the efficacy and safety of sequential versus quadruple regimens as second line treatment for persistent Helicobacter pylori infection. METHODS...

furazolidone (fzd), a nitrofuran derivative, is an antibacterial agent in use by the medical and veterinary fields. the chinese have utilized fzd to relieve stomach pain, 5 years before the discovery of helicobacter pylori. this drug is currently a part of helicobacter pylori's eradication regimen. however, some carcinogenic and toxic adverse effects associated with fzd have been observed in an...

The global polio eradication program, started in 1988, initially targeted the year 2000 for the worldwide elimination of the disease. Although poliovirus transmission has been markedly reduced, it has not been eliminated. As we enter the 20th year of the campaign, poliovirus continues to infect and cause paralysis in localized areas of South Asia and sub-Saharan Africa. To combat this scourge, ...