نتایج جستجو برای: excisional wound

تعداد نتایج: 72218  

Ian Rabinowitz, Mohammad Vasef, Mohammad Houman Fekrazad, Omid Sanaei, Shalini Ravi-Kumar,

A forty two years old woman with a history of bilateral breast augmentation for cosmetic reasons was presented for poor healing of the surgical site. Tissue and periprosthetic fluid were removed from the wound site revealing an atypical lymphoid infiltrate. Subsequently the patient developed axillary lymph adenopathy. Excisional biopsy was performed. Flow cytometry was non-diagnostic. She conti...

Journal: :Surgery 2002
Mark A Carlson Michael T Longaker Jon S Thompson

BACKGROUND Clinical experience suggests that granulation tissue may be inhibited by coverage with a musculocutaneous flap. We hypothesized that coverage of an open wound with a musculocutaneous flap would result in regression and apoptosis of the wound's granulation tissue. METHODS In the first experiment, 32 rats underwent excisional wounding; 16 underwent musculocutaneous flap coverage of t...

2017
Kelvin Kian Long Chong Wei Hong Tay Baptiste Janela Adeline Mei Hui Yong Tze Horng Liew Leigh Madden Damien Keogh Timothy Mark Sebastian Barkham Florent Ginhoux David Laurence Becker Kimberly A Kline

Enterococcus faecalis is one of the most frequently isolated bacterial species in wounds yet little is known about its pathogenic mechanisms in this setting. Here, we used a mouse wound excisional model to characterize the infection dynamics of E faecalis and show that infected wounds result in 2 different states depending on the initial inoculum. Low-dose inocula were associated with short-ter...

Ali Hatef Salmanian Ghasem Mosayebi, Hamid Abtahi, Maryam Baazm, Mohsen Khaki, Neda Molaee Saeed Babaei

Objective(s): Vascular endothelial growth factor (VEGF) is one of the most effective proteins in angiogenesis, mesenchymal stem cells (MSCs) differentiation and wound healing. These abilities are therapeutic potential of VEGF in diabetic retinopathy, nephropathy and other tissue damage circumstances. In this study, recombinant VEGF was produced in Escherichia coli (E. coli) system and then biol...

Journal: :Journal of diabetes research 2016
Xiao-Na Zhang Ze-Jun Ma Ying Wang Yu-Zhu Li Bei Sun Xin Guo Cong-Qing Pan Li-Ming Chen

Impaired wound healing in diabetic patients is a serious complication that often leads to amputation or even death with limited effective treatments. Tuo-Li-Xiao-Du-San (TLXDS), a traditional Chinese medicine formula for refractory wounds, has been prescribed for nearly 400 years in China and shows good efficacy in promoting healing. In this study, we explored the effect of TLXDS on healing of ...

2014
Ditte M S Lundvig Alwin Scharstuhl Niels A J Cremers Sebastiaan W C Pennings Jeroen te Paske René van Rheden Coby van Run-van Breda Raymond F Regan Frans G M Russel Carine E Carels Jaap C Maltha Frank A D T G Wagener

Impaired wound healing can lead to scarring, and aesthetical and functional problems. The cytoprotective haem oxygenase (HO) enzymes degrade haem into iron, biliverdin and carbon monoxide. HO-1 deficient mice suffer from chronic inflammatory stress and delayed cutaneous wound healing, while corneal wound healing in HO-2 deficient mice is impaired with exorbitant inflammation and absence of HO-1...

Journal: :The Journal of Experimental Medicine 1997
M. Carmen Montesinos Pratap Gadangi Michael Longaker Joanne Sung Jamie Levine Diana Nilsen Joan Reibman Min Li Chuan-Kui Jiang Rochelle Hirschhorn Phoebe A. Recht Edward Ostad Richard I. Levin Bruce N. Cronstein

The complete healing of wounds is the final step in a highly regulated response to injury. Although many of the molecular mediators and cellular events of healing are known, their manipulation for the enhancement and acceleration of wound closure has not proven practical as yet. We and others have established that adenosine is a potent regulator of the inflammatory response, which is a componen...

2011
Sae Hee Ko Allison Nauta Shane D. Morrison Hongyan Zhou Andrew Zimmermann Geoffrey C. Gurtner Sheng Ding Michael T. Longaker

Diabetic wounds remain a major medical challenge with often disappointing outcomes despite the best available care. An impaired response to tissue hypoxia and insufficient angiogenesis are major factors responsible for poor healing in diabetic wounds. Here we show that the antimycotic drug ciclopirox olamine (CPX) can induce therapeutic angiogenesis in diabetic wounds. Treatment with CPX in vit...

2006
Demetrius A Miminas

Demetrius A Miminas is a Post-graduate MSc Student in Wound Healing and Tissue Repair, Wound Healing Research Unit, Cardiff, and Trust-grade Plastic Surgeon, Russells Hall Hospital, Dudley Group of Hospitals NHS Trust, Dudley Early excision and grafting of burn wounds has largely replaced the conservative, non-excisional approach, due mainly to improvements in resuscitation and the introduction...

Journal: :The Journal of biological chemistry 2004
Irmgard S Thorey Boris Hinz Andreas Hoeflich Susanne Kaesler Philippe Bugnon Martin Elmlinger Rüdiger Wanke Eckhard Wolf Sabine Werner

An increasing number of patients are being treated with growth hormone (GH) for the enhancement of body growth but also as an anti-aging strategy. However, the side effects of GH have been poorly defined. In this study we determined the effect of GH on wound repair and its mechanisms of action at the wound site. For this purpose, we performed wound healing studies in transgenic mice overexpress...

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