RATIONALE Fever of unknown origin (FUO) can be determined by different conditions among which infectious diseases represent the main cause. PATIENT CONCERNS A young woman, with a history of aortic stenosis, was admitted to our unit for a month of intermittent fever associated with a new diastolic heart murmur and splenomegaly. Laboratory tests were negative for infectious screening. The total...

This disease has been defined as systemic arthritis by the International League of Associations for Rheumatology (ILAR) classification of juvenile idiopathic arthritis (JIA), 2 systemiconset juvenile rheumatoid arthritis (JRA) by the American College of Rheumatology Classification, or systemic-onset juvenile chronic arthritis by the European League against Rheumatism classification. Diagnosis o...

Background: Systemic lupus erythematosus (SLE) is an inflammatory autoimmune disorder which is uncommon in men. It has a wide variety of clinical presentations. Case Report: We report a 21-year-old male presented with one month history of fever, loss of appetite, weight loss and reduced hair growth with an examination revealing an oral ulcer, cervical and axillary lymphadenopathy simulating ...

Recurrent episodic fever of unknown origin (FUO) arising from tumour of the gastrointestinal tract is rare. We report an otherwise healthy 62-year-old man with recurrent circumscribed bouts of fever and raised CRP for 3 years who has remained well and fever-free 2 years after the removal of a well-differentiated adenocarcinoma of the colon. Occult colonic neoplasm should be considered and sough...

The aim of the article is to discuss issues associated with the occurrence of febrile illnesses in leisure and business travellers, with a particular emphasis on fevers of unknown origin (FUO). FUO, apart from diarrhoeas, respiratory tract infections and skin lesions, are one of the most common health problems in travellers to tropical and subtropical countries. FUO are manifestations of variou...

OBJECTIVE To describe the spectrum of diseases that may give rise to fever of unknown origin in elderly patients and to delineate the diagnostic approach in these patients. DESIGN Subgroup analysis of a prospectively collected case series followed more than 2 years. SETTING General Internal Medicine Service based at University hospital, Leuven, Belgium. PATIENTS Forty-seven consecutive pa...

Fever of unknown origin (FUO) remains to be a challenge despite advancement in diagnostic technologies and procedures. FUO is considered when fever presents intermittently without an explanation. It has been linked to various etiologies, which makes it difficult to diagnose. We present the case of 18-month-old female with recurrent fever, splenomegaly, abdominal pain, and constipation. The work...

Evaluation of elderly patients who have fever of unknown origin (FUO) requires a different perspective from that needed for young patients. Differential diagnosis often varies with age, and presentation of the disease frequently is nonspecific and symptoms difficult to interpret. Noninfectious diseases are the most frequent cause of FUO in the elderly and temporal arteritis the most frequent sp...

n engl j med 368;3 nejm.org january 17, 2013o 197 as they define it — a tempera­ ture rising above 38.3°C (101°F) on several occasions over a peri­ od of more than 3 weeks, for which no diagnosis has been reached despite 1 week of inpa­ tient investigation — is con­ sidered classic FUO. In the past 60 years, clinician­scientists have tracked the changing causes of these problematic fevers, as d...