Microarrays for genomic analysis pose a rather serious challenge for statistical inference on the quality of data. With the ability to attach large genomic fragments on the array substrate, it is now possible to search for chromosomal imbalances related to various diseases at a significantly improved resolution. The challenge lies in understanding the experimental characteristics and modeling t...

a rain gauge network should serve general as well as specific purposes such as water supply, hydropowergeneration, flood forecasting, irrigation, and flood control. the level of accuracy a network can achieve depends onthe number and locations of gauges in the network. in this study, a rain gauge network was designed for hormozganprovince in the south of iran. monthly rainfall totals from 124 r...

This paper attempts to introduce readers with the concept and methodology of bootstrap in Statist ics, which is placed under a larger umbrella of resampling. Major port ion of the discussions should be accessible to any one who has had a couple of college level applied stat istics courses. Towards the end, we attempt to provide glimpses of the vast l i terature published on the topic, which sho...

A new method for predicting protein-coding regions in microbial genomic DNA sequences is presented. It uses an ab initio iterative Markov modeling procedure to automatically perform the partition of genomic sequences into three subsets shown to correspond to coding, coding on the opposite strand, and noncoding segments. In contrast to current methods, such as GENEMARK [Borodovsky, M. & McIninch...

Genomic prediction methods based on multiple markers have potential to include nonadditive effects in prediction and analysis of complex traits. However, most developments assume a Hardy-Weinberg equilibrium (HWE). Statistical approaches for genomic selection that account for dominance and epistasis in a general context, without assuming HWE (e.g., crosses or homozygous lines), are therefore ne...

PURPOSE To identify genomic targets for ciliochoroidal melanoma diagnosis, prognosis, and therapy. METHODS Fifty-eight ciliochoroidal melanomas were analyzed by high-resolution, genome-wide, single nucleotide polymorphism (SNP) mapping arrays. The 58 SNP arrays were compared to 48 HapMap normals representing both sexes and assessed with a systematic statistical method, Genomic Identification ...