Tramadol is a centrally acting analgesic drug extensively metabolized in animal species. Its clinicalresponse is mainly due to the M1 metabolite, poorly produced in dogs. Grapefruit-juice can inhibit themetabolism of different drugs in animals and humans. The aim of the present study was to evaluate thepharmacokinetics of tramadol and its major metabolites after co-administration of tramadol an...

dopaminergic signaling is one of the regulatory pathways being investigated for its implication in glucose metabolism. the aim of this study was to determine the effect of cabergoline on biochemical and anthropometric parameters in prediabetes stage (impaired fasting glucose and impaired glucose tolerance). in this double blind, placebo-controlled, pilot study, 27 prediabetic adults were random...

We conducted research to evaluate whether ergot alkaloids associated with endophyte-infected tall fescue could alter plasma concentrations of hormones important to reproductive function in cows. Six primiparous, estrous-cycling Holstein cows nursing calves received single i.v. injections of ergotamine tartrate, ergonovine maleate, or saline vehicle in a simple cross-over design. Each cow receiv...

Dopaminergic signaling is one of the regulatory pathways being investigated for its implication in glucose metabolism. The aim of this study was to determine the effect of cabergoline on biochemical and anthropometric parameters in prediabetes stage (impaired fasting glucose and impaired glucose tolerance). In this double blind, placebo-controlled, pilot study, 27 prediabetic adults were random...

background autologous platelet concentrate has been used to improve the function and regeneration of injured tissues. tendinopathies are common in clinical practice, although long-term treatment is required. on the basis of lead time, we compared the effect of using platelet-rich plasma (prp) and platelet-rich fibrin (prf) in repairing rat achilles tendon. methods the effectiveness of using prp...

OBJECTIVE Leptin, the obese gene product, is thought to regulate body fat through its action on hypothalamic receptors that influence satiety. The hormonal regulation of leptin is important, since it might affect adiposity. Leptin regulation in man is poorly understood. We studied the relation between endogenous cortisol and leptin levels as well as the acute and chronic effects of a low dose o...

Background: Polycyclic aromatic hydrocarbons (PAHs) such as naphthalene (NAP) are organic pollutants that have spread widely in littoral marine ecosystems. We aimed to study the effect of acute and prolonged exposure to naphthalene (NAP) on plasma cortisol and thyroid levels in mature and immature Liza klunzingeri mulet. Methods: In acute stress experiment, the treatment group received 2μ...