Abstract The biocatalytic kinetic resolution of cyclic carbonates derived from glycerol is reported. A selection 26 esterases and lipases was tested for the asymmetric hydrolysis model substrate (epichlorohydrin carbonate) in aqueous medium. Among them, Pig Liver Esterase Novozym® 435 showed best selectivity with E =38 49, respectively. Both enzymes were employed conversion 12 derivatives under...

Halogenated natural products are frequently reported metabolites in marine seaweeds. These compounds span a range from halogenated indoles, terpenes, acetogenins, phenols, etc., to volatile halogenated hydrocarbons that are produced on a very large scale. In many cases these halogenated marine metabolites possess biological activities of pharmacological interest. Given the abundance of halogena...

Graphyne and graphdiyne families of flat carbon (sp2/sp) networks with high degrees of π-conjunction are attracting much attention due to their promising electronic, optical, and mechanical properties. In the present investigation we have studied the structural, mechanical, electrical and optical properties of halogenated graphdiyne and graphyne. The optical spectra of pure and halog...

Phenol is added to acetophenone (methyl phenyl ketone) and six of its halogenated derivatives in a supersonic jet expansion determine the hydrogen bonding preference cold isolated 1:1 complexes by linear infrared spectroscopy. Halogenation found have pronounced effect on docking site this intermolecular ketone balance experiment. The spectra unambiguously decide between competing variants group...

Chalcones, i.e., compounds with the chemical pattern of 1,3-diphenylprop-2-en-1-ones, exert a wide range of bio-activities, e.g., antioxidant, anti-inflammatory, anticancer, anti-infective etc. Our research group has been focused on pyrazine analogues of chalcones; several series have been synthesized and tested in vitro on antifungal and antimycobacterial activity. The highest potency was exhi...