BACKGROUND We determined the value of the inferior vena cava (IVC) diameter for predicting acute blood loss in control and blunt trauma patients and compared this with other parameters of hemorrhagic shock. METHODS Fifty volunteers and 28 consecutive hemorrhagic shock patients were recruited prospectively to participate in the study. Vital signs, blood lactate, and serum bicarbonate were meas...

Hemorrhagic shock is a leading cause of trauma-related mortality in both civilian and military settings. Resuscitation often results in reperfusion injury and survivors are susceptible to developing multiple organ failure (MOF). The impact of fed state on the overall response to shock and resuscitation has been explored in some murine models but few clinically relevant large animal models. We h...

BACKGROUND AND OBJECTIVES The aim of this paper is to report a case in which the damage control resuscitation (DCR) approach was successfully used to promote hemostatic resuscitation in a polytraumatized patient with severe hemorrhagic shock. CASE REPORT Female patient, 32 years of age, with severe hemorrhagic shock due to polytrauma with hip fracture, who developed acidosis, coagulopathy, an...

Metabolic staging after trauma/hemorrhagic shock is a key driver of acidosis and directly relates to hypothermia and coagulopathy. Metabolic responses to trauma/hemorrhagic shock have been assayed through classic biochemical approaches or NMR, thereby lacking a comprehensive overview of the dynamic metabolic changes occurring after shock. Sprague-Dawley rats underwent progressive hemorrhage and...

BACKGROUND The acute coagulopathy of trauma is multifactorial, but generally believed to be aggravated by coexisting acidosis, hypothermia, and hemodilution. While acidosis and hypothermia have been extensively evaluated, there is a paucity of data on the independent role of hemodilution in this scenario. We therefore hypothesized that hemodilution will impair coagulation following experimental...

IT HAS BEEN proposed that the vasotoxic aspects of irreversible shock are due to the release of an iron-bearing protein, ferritin, into the circulation, and that the vasoinhibitory properties of ferritin, in turn, are due to the action of iron associated with this piotein. These impressions were gained, in the main, in experiments involving hemorrhagic shock. Recently, work in our laboratory ha...

1029-1032. 1g5g.-The effectiveness of levarterenol in the treatment of shock resulting from prolonged oligemia was studied in the dog. The survival time of animals receiving levarterenol and whole blood therapy was significantly greater than that of animals receiving a placebo and whole blood. The results of the experiments indicate that levarterenol is an effective adjunct to whole blood thera...