introduction: the effect of severe soft tissue injury on the severity of hemorrhagic shock is still unknown. therefore, the present study was aimed to determine hemodynamic and metabolic changes in traumatic/hemorrhagic shock in an animal model. methods: forty male rats were randomly divided into 4 equal groups including sham, hemorrhagic shock, soft tissue injury, and hemorrhagic shock + soft ...

conclusions this study suggests that obese patients in hs may have a higher risk of hemodynamic instability compared to their nonobese counterparts primarily due to obesity-induced increases in intra-abdominal pressure resulting in reduced venous return. results in hemorrhage simulation, moderate increases in bmi were found to produce greater decreases in map and co compared to the normal subje...

introduction: different vasoactive factors can modulate cardiovascular adaptation to hemorrhagic shock including nitric oxide (no). in this study we investigated the effect of  the no synthase inhibitor for treatment of  decompensated hemorrhagic shock in normotensive and hypertensive rats. methods: twenty‑four male wistar rats were divided into two groups: the normotensive and hypertensive gro...

myocardial performance, utilizing the isolated canine heart preparation, was studied in two groups: normal control dogs and those subjected to hemorrhagic shock. a marked deterioration in myocardial functional capacity was observed in the shock group. from this study, myocardial incapacity resulting from the period of acute hypotension is felt to be a contributing factor in the death of animals...

Objective- The aim of this study was to assess ultrasonography-derived caudal vena cava to aorta ratio (CVC/Ao) as a novel endpoint in the resuscitation of experimental hemorrhagic shock in dogs. Design- Experimental study. Animals- Ten adult mongrel healthy dogs. Procedures- After induction of anesthesia (con...

although the majority of the patients with traumatic brain injury presents with injuries involving the extremities, there was a clear paucity of adequate experimental polytrauma models. to close this gap, we conducted several studies to establish two different polytrauma mice models including both closed and open traumatic brain injury. male c57bl mices with a mean weight of 23g were anesthetiz...

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BACKGROUND: GReliable prediction of patient response to fluid resuscitation is a crucial issue in the management of hemorrhagic shock. OBJECTIVES: This study was designed to investigate vertebral heart score (VHS) variation in fluid resuscitation of hemorrhagic shock patients and the feasibility of this method in determining resuscitation endpoint.  METHODS: VHS values were assessed using previ...

Introduction: In the recent years, effect of hypertonic solution in resuscitation of shock has been shown by clinical and laboratory studies. On the other hand ATP-MgCl2 is used for better tissue perfusion and cardiac output in shock. The aim of this study is evaluation of ATP-MgCl2 with hypertonic solution in resuscitation of hemorrhagic shock. Materials and Methods: In this experimental stud...

introduction: during hemorrhagic shock (hs), the kidneys are one of the primary target organs involved. oxidative stress is shown to be enhanced in different models of acute kidney injury (aki). remote ischemic preconditioning (rpc) by brief limb ischemia is considered to be a safe method to protect different organs from further damage. in this study, we investigated the effects of brief hind l...