Six triterpene acids identified as betulinic, oleanolic, ursolic, 3-epimaslinic, alphitolic and euscaphic acids have been isolated from a dichloromethane extract of hairy root cultures of Ocimum basilicum L. (Lamiaceae). These cultures were obtained by genetic transformation using Agrobacterium rhizogenes. The extract as well as the isolated compounds were evaluated for their hepatoprotective a...

Goodyeroside A, a natural product isolated from the Goodyera species, possesses significant hepatoprotective activity and has a novel skeleton not previously observed in other synthetic drugs used for the treatment of hepatitis. Herein, we report a highly stereoselective synthesis of goodyeroside A and related analogs with varying substituents at the α position of the carbonyl group to explore ...

The present study was conducted to evaluate the hepatoprotective activity of different extracts of Tinospora cordifolia against carbon tetrachloride (CCl4) induced liver damage in rats. The pet ether, ethanol and aqueous extracts of various parts of the plant such as leaf, stem and root were tested at the dose of 200mg/kg body weight orally using Wistar albino rats and Silymarin was given as re...

Acute liver damage caused by acetaminophen overdose is a significant clinical problem and could benefit from new therapeutic strategies. Objective. This study investigated the hepatoprotective effect of Thymus vulgaris essential oil (TEO), which is used popularly for various beneficial effects, such as its antiseptic, carminative, and antimicrobial effects. The hepatoprotective activity of TEO ...

To investigate the hepatoprotective potential of ethanolinc grape seed extract on acetaminophen (APAP) induced liver toxicity in wistar rats. Silymarin was used as reference hepatoprotective agent. Liver injury was induced by APAP (2 gm/kg body weight, bw) on the 1st day of experiment. Vitis vinifera (V. vinifera)L seed extract (200 and 400 mg/kg bw) and silymarin (100 mg/ kg bw) was administer...

Thespesia lampas (Cav.) Dalz & Gibs an important folk medicinal plant was evaluated for hepatoprotective and antioxidant activity against carbon tetrachloride (CCl4) induced hepatic damage in rats. In the present study, the T. lampas stems extracts at dose of 200 mg/kg body wt. were administered orally once daily for nine days and on seventh day after one hour of drug administration CCl4 (1ml/k...

Cuscuta seeds and whole plant have been used to nourish the liver and kidney. This study was aimed to investigate the hepatoprotective activity of the ethanol extract of Cuscuta campestris Yunck. whole plant (CCEtOH). The hepatoprotective effect of CCEtOH (20, 100 and 500 mg/kg) was evaluated on carbon tetrachloride (CCl₄)-induced chronic liver injury. Serum alanine aminotransferase, aspartate ...

Introduction: Acacia catechu is a deciduous, thorny tree which grows up to 12-15 meter in height. In Hindi is called as Khair and in kannada Kachu. It has been used as used for the treatment of inflammation, diarrhheoa, fever. Aims: to evaluate the hepatoprotective effect of ethanolic extract of acacia catechu in paracetemol induced liver damage in experimental animals, rats was studied. Method...

the present study investigates the antioxidant potential of the ethyl acetate fraction of the aerial parts eclipta alba l. hassk (eaea) which was widely used as hepatoprotective plant. eaea was orally administered at doses of 50, 100 and 200 mg/kg for 7 days in male charles foster rats. the extent of hepatoprotective potential of e . alba was studied by assessing the biochemical parameters like...