The spatial analysis of crime and the current focus on hotspots has pushed the area of crime mapping to the fore, especially in regard to high volume offences such as vehicle theft and burglary. Hotspots also have a temporal component, yet police recorded crime databases rarely record the actual time of offence as this is seldom known. Police crime data tends, more often than not, to reflect th...

Certain cell types function as factories, secreting large quantities of one or more proteins that are central to the physiology of the respective organ. Examples include surfactant proteins in lung alveoli, albumin in liver parenchyma, and lipase in the stomach lining. Whole-genome sequencing analysis of lung adenocarcinomas revealed noncoding somatic mutational hotspots near VMP1/MIR21 and ind...

There is strong evidence that hotspots of meiotic recombination in humans are transient features of the genome. For example, hotspot locations are not shared between human and chimpanzee. Biased gene conversion in favor of alleles that locally disrupt hotspots is a possible explanation of the short lifespan of hotspots. We investigate the implications of such a bias on human hotspots and their ...

In allostery, a binding event at one site in a protein modulates the behavior of a distant site. Identifying residues that relay the signal between sites remains a challenge. We have developed predictive models using support-vector machines, a widely used machine-learning method. The training data set consisted of residues classified as either hotspots or non-hotspots based on experimental char...

In some species, meiotic recombination is concentrated in small genomic regions. These "recombination hotspots" leave signatures in fine-scale patterns of linkage disequilibrium, raising the prospect that the genomic landscape of hotspots can be characterized from sequence variation. This approach has led to the inference that hotspots evolve rapidly in some species, but are conserved in others...

Resource clumping (prey hotspots) and intraspecific competition may interact to influence predator foraging behaviour. Optimal foraging theory suggests that predators should concentrate most of their foraging activity on prey hotspots, but this prediction has received limited empirical support. On the other hand, if prey concentration at hotspots is high enough to allow its use by several indiv...

Continental aquatic species richness hotspots are unevenly distributed across the planet. In present-day Europe, only two centers of biodiversity exist (Lake Ohrid on the Balkans and the Caspian Sea). During the Neogene, a wide variety of hotspots developed in a series of long-lived lakes. The mechanisms underlying the presence of richness hotspots in different geological periods have not been ...

We describe the problem of classifying hundreds of millions of Wi-Fi hotspots using only connection and user count characteristics. We use a combination of deep learning and frequency analysis. Specifically, Convolution Neural Networks (CNN) capture the spatio-temporal relationship between adjacent connection/user counts across a 24hour × 7day matrix, while FFT (Fast Fourier Transforms) extract...