A novel approach for the regioselective preparation of rtct-tpcb (tpcb = tetrapyridylcyclobutanes) compounds promoted by polymolybdates under hydrothermal conditions is reported; these isomers are stabilised as counterions in inorganic-organic hybrid solids and are obtained in high to fair yield.

Dicarboxylic acids and their derivatives (esters and anhydrides) have been used as acylating agents in lipase-catalyzed reactions in organic solvents. The synthetic outcomes have been dimeric or hybrid derivatives of bioactive natural compounds as well as functionalized polyesters.

There are a vast number of interesting and useful compounds that are readily found in nature. Mother Nature has acquired ingenious ways of generating molecular diversity in living cells responsible for regulation of various biochemical events. This has inspired research into the synthesis of biologically active compounds for use as antibiotics or in cancer therapy, for example. This account pro...

EVSTATIEVA, Y., M. BADALOVA, G. CHERNEV, D. NIKOLOVA and V. SAVOV, 2013. New hybrid matrix for immobilization of Trichoderma viride SL-45. Bulg. J. Agric. Sci., Supplement 2, 19: 120–122 In this work Trichoderma viride SL-45, was investigated in new a hybrid matrix by immobilizing method. Vegetative culture of this strain was immobilized in four variations of sol-gel hybrid silica materials, co...

Rare merosesquiterpenoids, craterellins A-C (1-3), were isolated from cultures of basidiomycete Craterellus odoratus together with the previously known massarinolin C (4). Structures of 1-3 were elucidated on the basis of extensive spectroscopic analysis. Compounds 1-3 possess a rare, epoxymethylenecyclohexanetriol-bicyclofarnesane sesquiterpene hybrid skeleton. Compounds 1-4 were evaluated for...

The quantum-chemical calculations on the conformational properties of 2-flouro-2-oxo- 1,3,2-dioxaphosphorinane (1), 2-choloro-2-oxo-1,3,2-dioxaphosphorinane (2) and 2-bromo- 2-oxo-1,3,2-dioxaphosphorinane (3) have been investigated by means of ab initio molecular orbital (HF/6-311+G**) and hybrid density functional theory (B3LYP/6-311+G**) based methods and Natural Bond Orbital (NBO) interpreta...

Hybrid drugs are a promising strategy to address the growing problem of drug resistance, but the mechanism by which they modulate the evolution of resistance is poorly understood. Integrating high-throughput resistance measurements and genomic sequencing, we compared Escherichia coli populations evolved in a hybrid antibiotic that links ciprofloxacin and neomycin B with populations evolved in c...

Knotweed rhizomes and young sprouts are used in a traditional Asian medicine. Because knotweed rhizomes contain large amount of stilbenes and catechins, the main objective of this study was analysis of selected phenolic compounds, including stilbenes and catechins, in young spring sprouts of the knotweed genus (Japanese knotweed (Reynoutria japonica), Giant knotweed (Reynoutria sachalinensis), ...