Hypoxic vasodilation in skeletal muscle at rest is known to include β-adrenergic receptor-stimulated nitric oxide (NO) release. We previously reported that the augmented skeletal muscle vasodilation during mild hypoxic forearm exercise includes β-adrenergic mechanisms. However, it is unclear whether a β-adrenergic receptor-stimulated NO component exists during hypoxic exercise. We hypothesized ...

AOKI, VINCENT S., AND SUMNER M. ROBINSON. Hindquarters vascular responses in chronically hypoxic rats. Am. J. Physiol. 217(3) : 661-665. 1969.-Following 6 weeks exposure to a hypoxic environment, vascular responsiveness of the rat to lumbar sympathetic nerve stimulation (NS) and intra-arterial injections of norepinephrine (NE), epinephrine (E), and tyramine (T) was studied by autoperfusion of t...

Hypoxia, a common feature of the microenvironment in solid tumors, is associated with resistance to radiotherapy, reduced therapeutic response, and a poorer clinical outcome. In head and neck squamous cell carcinomas (HNSCC), the negative effect of hypoxia on radiotherapy can be counteracted via addition of hypoxic modification to the radiotherapy. To predict which patients harbor hypoxic tumor...

The metabolism of SR 4233 (3-amino-l,2,4-bentotriazine-l,4-dioxide), recently reported as highly toxic to hypoxic cells in vitro, was studied by using suspensions of Chinese hamster ovary cells. The rates of formation of two known reduction products, the 1-oxide and the unoxygenated 3aminobenzotriazine, were measured in aerobic and hypoxic cell suspen sions for drug treatments producing both hy...

PURPOSE Most tumors develop regions with hypoxic cells during growth, owing to permanent limitations in oxygen diffusion (chronic or diffusion-limited hypoxia) and/or transient limitations in blood perfusion (acute or fluctuating hypoxia). The aim of this study was to investigate the relative significance of chronic and acute hypoxia in the development of metastatic disease. EXPERIMENTAL DESI...

The emergence of a new hypoxic therapy regimen in which intervals alternate with hyperoxic (30 % O2) led to the need study effectiveness hypoxic-hyperoxic for treatment progressive myopia. An ophthalmologic was performed on 116 male patients from 8 21 years age severe Doppler cerebral vessels, determination indices functional respiratory system were carried out. Interval hypoxia-hyperoxia prove...

An anti-alpha-synuclein (alpha-SYN) monoclonal antibody produced in our laboratory was used to investigate the effect of repeated acute hypoxic treatments on the expression of alpha-SYN in the mouse cerebral cortex. Western blot analysis showed that the expression levels of alpha-SYN in the cortex changed accordingly upon hypoxic exposure times, as that the alpha-synuclein level significantly i...

PURPOSE Chemotherapy targets rapidly proliferating tumor cells, but spares slowly proliferating hypoxic cells. We hypothesized that nutrition of hypoxic cells would improve in intervals between chemotherapy, and that hypoxic cells destined to die without treatment would survive and proliferate. EXPERIMENTAL DESIGN We therefore evaluated repopulation and reoxygenation following chemotherapy, a...

A hypoxic environment is thought to be important for the maintenance of stemness and suppressing cell senescence, in stem cells. Therefore, a hypoxic condition is induced during cell expansion and/or induction of intended differentiation. However, the induction of these conditions requires a specially equipped hypoxia chamber and expensive gas mixtures, which are expensive and space-consuming. ...

The metabolism of SR 4233 (3-amino-1,2,4-bentotriazine-1,4-dioxide), recently reported as highly toxic to hypoxic cells in vitro, was studied by using suspensions of Chinese hamster ovary cells. The rates of formation of two known reduction products, the 1-oxide and the unoxygenated 3-aminobenzotriazine, were measured in aerobic and hypoxic cell suspensions for drug treatments producing both hy...