A periodic increase in blood pressure (BP) occurs during apneic episodes in patients with obstructive sleep apnea (OSA). Several factors including hypoxemia and an increase in heart rate (HR) were reported to be responsible for this increased BP. To examine the contribution of these two factors in increasing BP, 35 healthy male subjects (mean age±SD= 23.64±3.80) were studied in three experi...

Background: Alveolar hypoxia induces monophasic pulmonary vasoconstriction in vivo, biphasic vasoconstriction in the isolated pulmonary artery, and controversial responses in the isolated perfused lung. Pulmonary vascular responses to sustained alveolar hypoxia have not been addressed in the isolated perfused rat lung. In this study, we investigated the effect of sustained hypoxic ventilation o...

background: alveolar hypoxia induces monophasic pulmonary vasoconstriction in vivo, biphasic vasoconstriction in the isolated pulmonary artery, and controversial responses in the isolated perfused lung. pulmonary vascular responses to sustained alveolar hypoxia have not been addressed in the isolated perfused rat lung. in this study, we investigated the effect of sustained hypoxic ventilation o...

background: gemcitabine (2′, 2′-difluoro-2′- deoxycytidine, an analogue of deoxycytidine) is a relatively new drug with wide range of anti-cancer activity. in this study, radiosensitizing effects of gemcitabine was investigated on hela and mrc5 human originated cell lines under both chronically hypoxic and normoxic conditions using the micronucleus (mn) assay. materials and methods: for inducti...

Background: Recently, the Flattening Filter Free (FFF) beams, which allow a dose rate increase of up to four times compared to the normal dose rate, have been incorporated into radiation therapy machines. The aim of this study is to evaluate antitumor activity in hypoxic cells irradiated with different dose rates using FFF beams and to identify the casual mechanism for cellular damage during ir...

Background: Some respiratory diseases may induce alveolar hypoxia thereby hypoxic pulmonary vasoconstriction (HPV). However, the mechanisms of this physiologic phenomenon are not fully understood. This study was the first to investigate the role of anion exchanger in sustained HPV.Methods: Experiments were performed in the isolated perfused rabbit lung. After preparation, the lungs were divided...

Introduction: Holding the breath during exercise causes hypoxia. This study set out to investigate the effect of the 12-week hypoxic interval training on lung volume and records of elite swimmers in 50 and 100 meters breaststroke. Methods: In this quasi-experimental study, 22 male swimmers were randomly divided into the hypoxic interval training group (n: 13; age: 16.61±1.39 years; he...

a periodic increase in blood pressure (bp) occurs during apneic episodes in patients with obstructive sleep apnea (osa). several factors including hypoxemia and an increase in heart rate (hr) were reported to be responsible for this increased bp. to examine the contribution of these two factors in increasing bp, 35 healthy male subjects (mean age±sd= 23.64±3.80) were studied in three experiment...