BACKGROUND Anaplastic lymphoma kinase (ALK) gene rearrangement in non-small cell lung cancer (NSCLC) has been intensively studied. The gold standard for ALK detection is FISH, but this is not routinely conducted in clinical practice, so that the IHC method has a role. The aim of this study was to identify the incidence of ALK rearrangement and risk or prognostic factors for ALK positivity using...

This report describes a series of investigations conducted examining a number of specific factors that control air emissions associated with the dredging of Indiana Harbor and Canal (IHC) and associated IHC Confined Disposal Facility (CDF) operations. Three primary objectives were addressed: (1) measurement of Henry’s Law constants and sediment-water desorption constants for various chemicals i...

BACKGROUND Molecular tumor profiling (MTP) is a potentially powerful diagnostic tool for identifying the tissue of origin in patients with cancer of unknown primary (CUP). However, validation of the accuracy and clinical value of MTP has been difficult because the anatomic primary site in most patients is never identified. METHODS From March 2008 through January 2010, clinicopathologic data f...

In a series of 13 pancreas cancer specimens, EGF-R was evaluated by means of both immunohistochemistry (IHC) for protein expression and FISH for genetic amplification. The results were discording in 7 cases (IHC positive, FISH negative), while in the remaining 6 cases both IHC and FISH were negative. The possible clinical implications of these results are discussed.

INTRODUCTION HER2 status assessment became a mandatory test assay in breast cancer, giving prognostic and predictive information including eligibility for adjuvant anti-HER2 therapy. Precise and reliable assessment of HER2 status is therefore of utmost importance. In this study we analyzed breast cancer samples by a novel technology for concomitant detection of the HER2 protein and gene copy nu...

Rajabiani A1, Aaliepour A2, Tavangar M3, Meysamie AP4 1. Assistant Professor, Department of Pathology, Faculty of medicine, Tehran University of Medical Sciences 2. Resident, Department of Pathology, Faculty of medicine, Tehran University of Medical Sciences 3. Associate Professor, Department of Pathology, Faculty of medicine, Tehran University of Medical Sciences 4. Assistant Professor, Depar...

Heat shock protein 27 (hsp27) belongs to the family of heat shock proteins and is thought to be involved in thermotolerance, cell proliferation, drug resistance, and chaperone processes. The aim of this study was to investigate whether hsp27 levels are correlated with clinical outcome in axillary lymph node-negative breast cancer patients. We describe a Western blot study measuring hsp27 levels...