Abstracts: Information and knowledge (IK) are very important for any institution including education higher institution. Those IK are stored in every single individual in organization in the form of experiences, skills, etc. The growth of the higher education institution nowadays relies on how an institution manage the dissemination of those IK over the organization by using information technol...

The lower limb sidestepping kinematics of 20 elite female athletes were calculated using: 1) an established direct kinematic (DK) model (criterion) and, 2) two inverse kinematic (IK) models; one with and one without participant-specific joint co-ordinates prescribed during model preparation. The aim of this research was to determine whether prescribing joint co-ordinates influences the accuracy...

Intermediate-conductance Ca2+-activated K+ (IK) channels are calcium/calmodulin-regulated voltage-independent K+ channels. Activation of IK currents is important in vessel and respiratory tissues, rendering the channels potential drug targets. A variety of small organic molecules have been synthesized and found to be potent activators of IK channels. However, the poor selectivity of these molec...

Ikaros, a zinc finger-containing DNA-binding protein, is required for normal lymphocyte development, and germline mutant mice that express only non-DNA binding dominant-negative "leukemogenic" Ikaros isoforms lacking critical N-terminal zinc fingers develop an aggressive form of lymphoblastic leukemia 3-6 months after birth. Therefore, we sought to determine whether molecular abnormalities invo...

The graft-versus-leukemia (GVL) effect following allogeneic hematopoietic stem cell transplantation (allo-HCT) is critical for its curative potential. Hwever, GVL is tightly linked to graft-versus-host disease (GVHD). Among hematological malignancies, acute lymphoblastic leukemia (ALL) is the most resistant to GVL, although the reasons for this remain poorly understood. Clinical studies have id...

The role of a guanine nucleotide-binding protein (Gk) in the coupling between muscarinic receptor activation and opening of an inwardly rectifying K+ channel [IK(M)] was examined in cardiac atrial myocytes, using hydrolysis-resistant GTP analogues. In the absence of muscarinic agonist, GTP analogues produced a membrane current characteristic of IK(M). The initial rate of appearance of this rece...

Currents through the inward rectifier K channel (iK X rec) and the ACh-operated K channel (iK X ACh) were recorded in isolated heart cells of rabbit using the patch clamp technique with electrodes having 0.5-1 micron tip inner diameter. The maximum number of overlaps of open iK X rec channels per patch was measured over 347 experiments. An average of 2.3 was found in ventricular cells and 0.03-...

Araque, Alfonso, Alain Marchand, and Washington Buño. and Vassort 1975a). Therefore opener fibers provide a Voltage-gated and Ca-activated conductances mediating and unique preparation to quantitatively evaluate the relationcontrolling graded electrical activity in crayfish muscle. J. Neuroships between the waveforms and magnitudes of the ICa and physiol. 79: 2338–2344, 1998. Crayfish opener mu...

Individual myocytes were isolated from bullfrog atrium by enzymatic and mechanical dispersion, and a one-microelectrode voltage clamp was used to record the slow outward K+ currents. In normal [K+]o (2.5 mM), the slow outward current tails reverse between -95 and -100 mV. This finding, and the observed 51-mV shift of Erev/10-fold change in [K+]o, strongly suggest that the "delayed rectifier" in...