BACKGROUND It has been observed that the use of immunosuppressive drugs in patients after transplantation of vascularized organs may be associated with changes in the concentration of certain fractions of plasma proteins. The concentration of these proteins was correlated with an increased risk of occurrence of stage 3 chronic kidney disease (CKD). This article examines the effect of the most c...

Treating Central Nervous System (CNS) neuro-inflammational disorders is of great importance. A key aspect of this treatment includes regulation of Cell-Mediated and humoral immune systems. Previous treatment mostly consisted of systemic immunosuppressive drugs. In addition to having adverse side effects, these drugs were also inefficient, such as methotrexate- Cyclophosphamide-Azathioprine. Rec...

background and aim: steroid-resistant nephrotic syndrome (srns) accounts for 10%-20% of all cases of idiopathic nephrotic syndrome. these patients are at risk of developing end-stage renal disease. the aim of this study was to determine the demographic characteristics, renal biopsy findings, response to immunosuppressive treatment, and prognosis in pediatric patients with srns.materials and met...

strongyloidiasis is a frequent misdiagnosed parasitic infection in the world that caused by strongyloides stercoralis . in iran, the disease is predominantly reported from warm and humid climate provinces. the patient was a 54-yr-old man, originated from khuzestan province with a history of pemphigus and diabetes that was treated with high-dose of corticosteroid drugs before admission in a non-...

Survival after heart transplantation has improved considerably over the past 20 years. Half of all patients now live 9 years, and 25% live 17 years.1 Currently, 20 000 heart transplant recipients live in the United States.2 Improved longevity means prolonged immunosuppression and the concomitant use of drugs to prevent or treat the long-term complications of immunosuppressive agents, such as in...

Therapeutic drug monitoring (TDM) of immunosuppressive drugs has evolved over the last few decades. The use of liquid chromatography–tandem mass spectrometry, for example, now provides robust and highly specific quantification in the clinical laboratory. Nevertheless, the measurement of immunosuppressive drug concentrations, even if carried out accurately and precisely, does not sufficiently re...

Immunosuppressive drug therapy is required to treat patients with autoimmune disease and patients who have undergone organ transplantation. The main targets of the immunosuppressive drugs tacrolimus and mycophenolic acid (MPA; the active metabolite of mycophenolate mofetil) are T cells. It is currently unknown whether these immunosuppressive drugs have an effect on DNA methylation-an epigenetic...

INTRODUCTION In systemic sclerosis (SSc) little evidence for the effectiveness of anti-inflammatory and immunosuppressive therapy exists. The objective of this study was to determine the extent to which SSc patients are treated with corticosteroids and immunosuppressive agents. METHODS Data on duration and dosage of corticosteroids and on the type of immunosuppressive agent were analyzed from...