نتایج جستجو برای: inherited immune system
تعداد نتایج: 2450967 فیلتر نتایج به سال:
Abstract In recent years, immune systems have sparked considerable interest within the philosophy of science. One issue that has received increased attention is whether other phyla besides vertebrates display an adaptive system. Particularly discovery CRISPR-Cas9-based triggered a discussion about how to classify systems. question not been addressed yet transgenerational aspect response. If imm...
We here report the case of a 2-year-old patient with primary central nervous system lymphoma B-cell origin. Due to their past medical history repeated respiratory tract infections and marked chemotherapy-associated toxicity infectious comorbidity, we suspected that also suffered from an inherited immune deficiency disorder. Despite lack classical pathognomonic symptoms for ataxia teleangiectasi...
Since half of the genes are inherited from paternal side, maternal immune system has to tolerate presence foreign antigens. Regulatory T cells facilitate development and maintenance peripheral tissue tolerance fetus during pregnancy. Reduction in regulatory is associated with complications pregnancy, including spontaneous abortion. Recent studies mouse models have shown that adoptive transfer T...
Abstract Netherton syndrome is a rare genetic disorder inherited in an autosomal recessive pattern. Mutations the serine protease inhibitor Kazal-type 5 ( SPINK5 ) gene are responsible for this disorder. can have multisystemic effects primarily involving hair, skin and immune system. Currently, no definitive treatment has been reported beyond supportive care. Herein, we report case of newborn d...
To determine whether inherited variations in immune function single-nucleotide polymorphisms (SNPs), genes or pathways affect glioblastoma risk, we analyzed data from recent genome-wide association studies in conjunction with predefined immune function genes and pathways. Gene and pathway analyses were conducted on two independent data sets using 6629 SNPs in 911 genes on 17 immune pathways fro...
Non-inherited maternal antigens (NIMA) are those protein products derived from polymorphic genes that the mothers express but not the offspring. During normal human pregnancy, a bidirectional regulation occurs in such a way that the maternal immune system tolerates the inherited paternal antigens (IPA) expressed by the fetus and the developing fetal immune system tolerates NIMA. The process by ...
The hygiene hypothesis, as originally proposed, postulated an inverse relation between the incidence of infectious diseases in early life and the subsequent development of allergies and asthma. New evidence from epidemiological, biological and genetic studies has significantly enlarged the scope of the hypothesis. It now appears probable that environmental 'danger' signals regulate the pattern ...
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