Lornoxicam (Lnxc), a novel type of non-steroidal antiinflammatory drug developed by comely, was first listed in Denmark in October 1997 (trade name xefo). Clinically, it is used to treat rheumatoid, rheumatoid arthritis and osteoarthritis. The Lnxc with low drug concentration has a short half-life [1] after oral administration, leading to much side effect and therapy activity tended to be worse...

A frozen shoulder is a common cause of a painful and stiff shoulder. A web-based survey was conducted to obtain insight in the current preferences about the diagnosis and treatment of a frozen shoulder. A response rate of 54% was reached among shoulder specialized orthopaedic surgeons from the Netherlands and Belgium. Non-steroidal anti-inflammatory drugs and intra-articular corticosteroid inje...

OBJECTIVE To investigate the effect of osteoclastogenesis inhibitory factor/osteoprotegerin (OPG) on chondrocytes in the development of osteoarthritis (OA) in vivo. METHODS To determine the role of endogenous OPG in the progression of OA, OA was surgically induced in OPG+/- mice and their wild-type (WT) littermates. To determine the role of exogenous OPG, knee joints of C57BL/6J mice with sur...

Osteoarthritis (OA) is one of the main causes disability worldwide and caused by progressive degeneration joint tissues, ultimately leading to chronic pain loss function. Intraarticular delivery mesenchymal stromal cells, such as adipose-derived cells (ASCs), being actively investigated due their trophic properties observed in both preclinical clinical studies. However, cell expansion handling ...

ganglion cysts commonly occur around the shoulder, mostly in the spinoglenoid and suprascapular notches. we report a very rare case of intra articular ganglion cyst of the long head of the biceps tendon that originated from the bicipital groove as a rare cause of shoulder pain.

We previously reported increased release of the excitatory amino acid (EAA) neurotransmitters, glutamate and aspartate, during the early stage of experimental osteoarthritis (OA). Our present objective was to study the effect of intraarticular injection of hyaluronic acid (HA) on OA development, and to analyze concomitant changes in EAA levels in dialysates of anterior cruciate ligament-transec...

BACKGROUND The extended knee lateral midpatellar portal for intraarticular injection of the knee is accurate but is not practical for all patients. We hypothesized that a modified anteriolateral portal where the synovial membrane of the medial femoral condyle is the target would be highly accurate and effective for intraarticular injection of the knee. METHODS 83 subjects with non-effusive os...

OBJECTIVE To determine if supplemental intraarticular α2-macroglobulin (α2 M) has a chondroprotective effect in a rat model of osteoarthritis (OA). METHODS Using Western blotting, mass spectrometry, enzyme-linked immunosorbent assay (ELISA), and immunohistochemistry, α2 M was identified as a potential therapeutic agent through a comparison of α2 M concentrations in serum, synovial fluid (SF),...