background: this double-blinded, randomized clinical trial was designed to evaluate the comparison of intravenous versus intraarticular (ia) administration of midazolam on postoperative pain after knee arthroscopy. materials and methods: in this study, 75 patients randomized in three groups to receive 75 mc/kg ia injection of midazolam and 10 ml intravenous injection of isotonic saline (group i...

BACKGROUND Rheumatoid arthritis (RA) commonly involves the knee joint in up to 30% of patients. Musculoskeletal ultrasound enables the skilled clinician to easily assess disease activity. OBJECTIVE To evaluate the sensitivity to change of the sonography score of large joints in Rheumatology (SOLAR) for different treatments of knee arthritis in RA. METHOD Joints were assessed by ultrasound a...

background:  tranexamic acid (txa) has received extensive attention in management of blood loss in orthopedic surgeries. however, the ideal method of txa administration is still controversial. this study aims to determine whether intraarticular injection of txa reduces blood loss after total knee arthroplasty (tka).   methods:  through a retrospective case-control study consecutive tka patients...

Persistent inflammation is well known to promote the progression of arthropathy. mesenchymal stem cells (MSCs) have been shown to possess anti-inflammatory properties and tissue differentiation potency. Although the experience so far with the intraarticular administration of mesenchymal stem cell (MSC) to induce cartilage regeneration has been disappointing, MSC implantation is now being attemp...

Background:  Tranexamic acid (TXA) has received extensive attention in management of blood loss in orthopedic surgeries. However, the ideal method of TXA administration is still controversial. This study aims to determine whether intraarticular injection of TXA reduces blood loss after total knee arthroplasty (TKA).   Methods:  Through a retrospective case-control study consecutive TKA patients...

BACKGROUND Earlier results suggest that peripheral alpha(2)-adrenoceptors and opioid receptors may reduce arthritic pain. Fadolmidine is a highly selective alpha(2)-adrenoceptor agonist that has only limited central access after peripheral administration. We assessed the peripheral antinociceptive properties of fadolmidine and the potential contribution of peripheral opioid receptors to its ant...

In arthritic individuals who have only one or two peripheral joints causing difficulty, it would seem advisable to treat these joints locally by direct intraarticular injection of medication in an effort to decrease the incidence and severity of toxicity associated with systemic therapy. The first very effective anti-rheumatic preparation for intraarticular injection was hydrocortisone acetate ...

Background: Tranexamic acid (TXA) is effective in reduction of blood loss after major surgical procedures. In TKA surgeries, it commonly administered intravenously. Since there are contraindications systemic use TXA, local/intraarticular TXA can also be used. The efficacy both and local administration demonstrated the literature. aim was to assess effect intraarticular during total knee arthrop...