Volume 3 • Issue 2 • 1000132 Adv Tech Biol Med ISSN: 2379-1764 ATBM, an open access journal The bone is a very important organ that supports is one of the many bodily functions. It has very diverse functions from the general support of the human body to energy regulation and balance [1]. Bones are formed during the development either through intramembranous (flat bones) ossification or endochon...

Bone has the natural ability to remodel and repair. Fractures and small noncritical size bone defects undergo regenerative healing via coordinated concurrent development of skeletal and vascular elements in a soft cartilage callus environment. Within this environment bone regeneration recapitulates many of the same cellular and molecular mechanisms that form embryonic bone. Angiogenesis is inti...

The objective of the study was to investigate the feasibility of intramembranous osteogenesis from tissue-engineered bone membrane in vivo. Bone marrow mesenchymal stem cells (MSCs) of rabbits were harvested, expanded and some of them were induced into osteoblasts. Porcine small intestinal submucosa (SIS) was converted by a series of physical and chemical procedures into a scaffold. MSCs and in...

Bone development occurs by two mechanisms: intramembranous bone formation and endochondral bone formation. Bone tissue forms by eventual differentiation of osteoprogenitor cells into either mesenchymal osteoblasts (MOBL), which synthesize woven bone in random orientation, or surface osteoblasts (SOBL), which synthesize bone on surfaces in a well oriented lamellar array. Bone repair uses the sam...

Bone repair requires the mobilization of adult skeletal stem cells/progenitors to allow deposition of cartilage and bone at the injury site. These stem cells/progenitors are believed to come from multiple sources including the bone marrow and the periosteum. The goal of this study was to establish the cellular contributions of bone marrow and periosteum to bone healing in vivo and to assess the...

Objectives: The aim of this study was to investigate the combined effects of bone allograft and lowintensity pulsed ultrasound (LIPUS) on osteogenesis using a bone allograft model. Methods: Femora and tibiae were harvested from 8 Wistar rats. These long bones were used for bone allografts. Subsequently, two groups were studied. In the bone allograft group, freeze-dried bone was fixed unilateral...

Enhanced understanding of differential gene expression and biological pathways associated with distinct phases of intramembranous bone regeneration following femoral marrow ablation surgery will improve future advancements regarding osseointegration of joint replacement implants, biomaterials design, and bone tissue engineering. A rat femoral marrow ablation model was performed and genome-wide ...