statement of problem: it is not known whether endochondral and intramembranous bones have distinct biological characteristics. octacalcium phosphate (ocp), a hydroxyapatite precursor, has been reported to stimulate bone formation after being implanted in parietal bone defects of rats. purpose: the present study was designed to investigate the response of endochondral and intramembranous bones t...

bone is formed through the processes of endochondral and intramembranous ossification. in endochondral ossification primary mesenchymal cells differentiate to chondrocytes and then are progressively substituted by bone, while in intramembranous ossification mesenchymal stem cells (mscs) differentiate directly into osteoblasts to form bone. the steps of osteogenic proliferation, differentiation,...

Bone is formed through the processes of endochondral and intramembranous ossification. In endochondral ossification primary mesenchymal cells differentiate to chondrocytes and then are progressively substituted by bone, while in intramembranous ossification mesenchymal stem cells (MSCs) differentiate directly into osteoblasts to form bone. The steps of osteogenic proliferation, differentiation,...

The aim of the study was to assess quantitatively the amount of new bone formed in the early stages of healing of intramembranous and endochondral autogenous bone grafts so as to gain further insight into their integration with host bone. Eighteen critical size defects were created in the parietal bone of nine New Zealand White rabbits. In the experimental group (five rabbits), each rabbit was ...

The aim of this study was to investigate the temporal expression of TIMP-1 within endochondral and intramembranous bone grafts during the early stages of healing in thirty six adult New Zealand white rabbits. Total RNA was isolated from bone grafts extracted on days 0-11 and day 14 post-grafting, for RT-PCR analysis. In situ hybridization was carried out on days 1-9 and day 14. Results showed T...

INTRODUCTION The mammalian skull vault, which protects the brain, comprises bones derived from dual embryonic origins. Cells from both cranial neural crest (CNC) and paraxial mesoderm (PM) form skull progenitors, and these distinct populations are already spatially segregated in rostral and caudal domains above the eye in the mouse at E11.5 (Yoshida et al., 2008). Skull bones undergo intramembr...

INTRODUCTION: Bone regeneration occurs through a series of spatiotemporal events influenced by the mechanical environment, various local and systemic factors, and the embryological origin of the specific bone. Long bone fractures treated with flexible fixation heal primarily through endochondral ossification. Following an initial inflammatory phase, mesenchymal cells proliferate and undergo cho...

Bone is formed through the processes of endochondral and intramembranous ossification. In endochondral ossification primary mesenchymal cells differentiate to chondrocytes and then are progressively substituted by bone, while in intramembranous ossification mesenchymal stem cells (MSCs) differentiate directly into osteoblasts to form bone. The steps of osteogenic proliferation, differentiation,...