نتایج جستجو برای: intranasal
تعداد نتایج: 7735 فیلتر نتایج به سال:
The last two decades has seen progress in the development of potential mucoadhesive carriers for assisting with the oral and nasal administration of drugs based around the polysaccharide chitosan. This progress has been underpinned by the development of molecular assays for mucoadhesiveness focusing on the mucin component of mucus. We review the developments based around molecular or biophysica...
While enormous progress has been made regarding our understanding of the pathogenic mechanisms of neurological diseases, there are only a small number of effective drugs for treating these illnesses. A key obstacle for developing effective drugs for treating neurological diseases is the blockage of drug entrance into the CNS by the BBB [1]. Less than 2% of all small-molecule drugs, and virtuall...
Background and purpose: Painful stimulation during laryngoscopy and endotracheal intubation results in increased hemodynamic side effects. The aim of current study was to compare the effects of intranasal dexmedetomidine and remifentanil on reduction of hemodynamic changes following endotracheal intubation in children undergoing general anesthesia. Materials and methods: A double-blind clinica...
Introduction: Due to incomplete development of coping skills in children, they usually cannot cope with stressful situations like dental appointments. The present study aims to evaluate the effect of intranasal midazolam with/without inhalation sedation (N2O/O2) in children with high levels of dental anxiety. Materials and Methods: This crossover double-blinded clinical trial was conducted on 1...
BACKGROUND Patients with rhinitis often self-medicate with over-the-counter drugs, however this self-treating population has remained largely unstudied. OBJECTIVE To characterize individuals self-medicating persistent rhinitis and to determine the prevalence of and risk factors for intranasal decongestant overuse within this population. METHODS A cross-sectional observational study of indiv...
Intranasal administration is a method of delivering therapeutic agents to the central nervous system (CNS). It is non-invasive and allows large molecules that do not cross the blood-brain barrier access to the CNS. Drugs are directly targeted to the CNS with intranasal delivery, reducing systemic exposure and thus unwanted systemic side effects. Delivery from the nose to the CNS occurs within m...
OBJECTIVE Treatment of severe hypoglycemia with loss of consciousness or seizure outside of the hospital setting is presently limited to intramuscular glucagon requiring reconstitution immediately prior to injection, a process prone to error or omission. A needle-free intranasal glucagon preparation was compared with intramuscular glucagon for treatment of insulin-induced hypoglycemia. RESEAR...
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