نتایج جستجو برای: ischemic postconditioning

تعداد نتایج: 85574  

2011
Jin Mo Kim Young Ho Jang Jun Kim

During the past few decades, a large number of animal studies demonstrated that commonly used opioids could provide cardioprotection against ischemia-reperfusion (I/R) injury. Opioid-induced preconditioning or postconditioning mimics ischemic preconditioning (I-Pre) or ischemic postconditioning (I-Post). Both δ- and κ-opioid receptors (OPRs) play a crucial role in opioid-induced cardioprotectio...

Background and aim: Acute kidney injury (AKI) is a frequent complication of kidney failure with high mortality which leads to brain dysfunction. The aim of this study was to investigate the possible protective effect of ischemic postconditioning (IPo) against brain dysfunction induced by bilateral renal ischemia (BRI). Materials and methods: Male Wistar rats underwent BRI, sham or IPo surgery ...

Journal: :Seminars in cardiothoracic and vascular anesthesia 2010
Jacob Raphael

Perioperative myocardial ischemia and infarction are not only major sources of morbidity and mortality in patients undergoing surgery but also important causes of prolonged hospital stay and resource utilization. Ischemic and pharmacological preconditioning and postconditioning have been known for more than two decades to provide protection against myocardial ischemia and reperfusion and limit ...

Journal: :Turkish neurosurgery 2016
M Ozgur Taskapilioglu Tugba Morali Guler Gokhan Ocakoglu Ender Korfali

Intracranial aneurysms and their treatment is one of the leading problems of neurosurgery that create high mortality and morbidity. The technique of safe clipping is as generally used depends on the temporary occlusion of the cerebral vasculature during surgery. However, there is no exact data about temporary clipping or timing of this procedure. Preconditioning by exposure to sublethal hypoxic...

Journal: :Annals of Clinical and Translational Neurology 2019

Journal: :Circulation research 2008
Kerstin Boengler Astrid Buechert Yvonne Heinen Christin Roeskes Denise Hilfiker-Kleiner Gerd Heusch Rainer Schulz

The cardioprotection by ischemic preconditioning is lost in aged wild-type and in STAT3 (signal transducer and activator of transcription 3)-deficient mice. The aim of the present study was to analyze whether or not ischemic postconditioning (iPoco) was effective in aged mice hearts and whether iPoco was dependent on STAT3. Young (3 months) and aged (>13 months) C57Bl6/J mice underwent 30 minut...

2010
Marek Treiman Thomas Engstrøm

Acute myocardial infarction is a major cause of death and heart failure in western society [1]. Introduction of reperfusion therapy in terms of thrombolysis and primary percutaneous coronary intervention (PPCI) has lead to a significant decreases in morbidity and mortality [2]. Today, PPCI is the recommended therapy for patients with ST-segment elevation myocardial infarction (STEMI). However, ...

Journal: :Acta medica Iranica 2015
Alireza Imani Maryam Khansari Yaser Azizi Kamran Rakhshan Mahdieh Faghihi

Postconditioning is a simple and safe strategy for cardioprotection and infarct size limitation. Our previous study showed that oxytocin (OT) exerts postconditioning effect on ischemic/reperfused isolated rat heart. The aim of this study was to investigate the involvement of OT receptor, mitochondrial ATP-sensitive potassium channel (mKATP), nitric oxide (NO) and cyclooxygenase (COX) pathways i...

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