Systemic administration of ISIS 2302, a 20-mer antisense phosphorothioate oligonucleotide targeting human intercellular adhesion molecule-1 mRNA, causes prolongation of plasma clotting times in both monkey and human studies. The anticoagulant effects of ISIS 2302 were investigated with both in vitro coagulation assays in human plasma and purified enzyme systems. At high oligonucleotide plasma c...

The present study was designed to determine the maximum tolerated dose (MTD), toxicity profile, pharmacokinetics (PKs), and antitumor activity of the protein kinase Cantisense oligonucleotide ISIS 3521 (ISIS Pharmaceuticals, Inc., Carlsbad, CA) when administered in combination with 5-fluorouracil (5-FU) and leucovorin (LV). Patients with refractory solid tumors received ISIS 3521 as a 21-day co...

The applicability of Model Based Networked Control Systems (MB-NCS) is often limited by the inexact knowledge of the dynamics of the system being controlled. On-line identification of system parameters is used in this paper to upgrade the model of the system, which is used to control the real system when feedback information is unavailable. Background material is offered on the topic of paramet...

ISIS 388626 is an antisense sodium-glucose cotransporter 2 (SGLT2) inhibitor designed to treat type 2 diabetes mellitus by induction of glucosuria. ISIS 388626 was demonstrated to be safe and effective in preclinical trails in several species. We undertook the present study to evaluate the safety and efficacy of 13 weekly doses of 50, 100, and 200 mg of ISIS 388626 in humans. ISIS 388626 increa...

The pharmacokinetics of a 2'-O-(2-methoxyethyl)-modified oligonucleotide, ISIS 301012 [targeting human apolipoprotein B-100 (apoB-100)], was characterized in mouse, rat, monkey, and human. Plasma pharmacokinetics following parental administration was similar across species, exhibiting a rapid distribution phase with t(1/2alpha) of several hours and a prolonged elimination phase with t(1/2beta) ...

Basilosauridae are cosmopolitan fully-aquatic archaeocete whales, represented by larger Basilosaurus isis and smaller Dorudon atrox in the middle-to-late Eocene Gehannam and Birket Qarun Formations of Egypt (ca. 38-36.5 Ma). Adult and juvenile Dorudon but only adult Basilosaurus are found in these shallow-marine deposits. Lethal bite marks on juvenile Dorudon skulls sparked the idea that adult ...

Incidence of double discharges (DDs; >100 Hz) and short interspike intervals (ISIs; >50 to <100 Hz) is reported to vary widely among different muscles and tasks, with a higher incidence in motor unit (MU) trains of fast muscles and for the production of fast contractions in humans. However, it is unclear whether human muscles with a large composition of slower motor units exhibit DDs or short I...

We designed and implemented the electric scheme of solar panels in PROUTEUS ISIS-Capture accordance with their architecture this work, which concentrates on how to create a specific library any commercially available that environment. Currently, existing photovoltaic panel models are mostly based MATLAB or PSPICE software, barely ISIS-PROTEUS software. This paper focuses model cells PROTEUS ena...

This paper presents a new algorithm to implement causal ordering. Causal ordering was first proposed in the ISIS system developed at Cornell University. The interest of causal ordering in a distr ibuted system is that it is cheaper to realize than total ordering. The implementation of causal ordering proposed in this paper uses logical clocks of Mat te rn-Fidge (which define a partial order bet...

In recent years application of CFRP sheets in the strengthening of the concrete circular column has increased numerously. Knowing the exact behavior of concrete cylindrical columns confined with CFRP is of the first order of importance. ISIS Code of Canada has given relations for strength increase of circular columns confined with CFRP sheets, these relations are defined for a specified range o...