BACKGROUND Magnetic resonance imaging (MRI) is increasingly used for research in hand osteoarthritis, but imaging the thin cartilage layers in the hand joints remains challenging. We therefore assessed the accuracy of MRI in detecting cartilage loss in patients with symptomatic osteoarthritis of the first carpometacarpal (CMC1) joint. METHODS Twelve patients scheduled for trapeziectomy to tre...

The first metatarsophalangeal joint (MTPJ1) plays a crucial role in human locomotor movements [1,2,3] but little is known about the articular cartilage of this joint. Previous studies to determine the MTPJ1 cartilage thickness have used the creep indentation [4] or histomorphometric techniques [5]. To the best of our knowledge, imaging has not yet been used for this purpose although it has the ...

common cause of degenerative joint disease (DJD) in dogs, is a chronic, progressive, noninfectious joint disorder that leads to degeneration of articular cartilage and proliferative changes. Damage to articular cartilage may result from abnormal stresses that disrupt the normal articular surface, in turn leading to joint instability. Consequently, the normal wear pattern as well as the turnover...

It is well understood that proper joint kinematics and loading are important factors in maintaining the health of the articular cartilage of the knee. This state of normal, physiologic loading facilitates a balance between anabolic and catabolic processes resulting in low level, homeostatic cartilage matrix turn-over and remodeling. In this way articular cartilage can function throughout an ent...

important functions: joint lubrication, stress distribution to subchondral bone to minimize peak stress, and provision of a smooth low-friction surface. Repetitive and acute impact, as well as torsional joint loading can damage articular cartilage surfaces of the knee joint. Injury to articular cartilage can lead to pain, swelling, joint dysfunction, and possibly progressive joint degeneration....

The administration of 0-2-0-4 mCi 90 yttrium (90Y) into a normal rabbit knee joint fails to induce medical synovectomy and results in the proliferation of the synovialis. The synovial mesothelium shows early radiation damage but subsequently follows a restitution of the whole. Later (within 4 to 16 weeks) an extensive fibrosis of the stratum synovialis develops, as well as an occlusion and scle...

Cartilage lesions are at a high prevalence in dysplastic hips and may relate to arthritic changes and hip joint dysfunction. To date, the effectiveness of repair of articular cartilage defects in the dysplastic hips has not yet been thoroughly evaluated. Here we retrospectively reviewed the effects of acetabuloplasty procedures with/without concomitant autologous tibial periosteal transplantati...